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Enhancing prime editor flexibility with coiled-coil heterodimers.
Mu S, Chen H, Li Q, Gou S, Liu X, Wang J, Zheng W, Chen M, Jin Q, Lai L, Wang K, Shi H. Mu S, et al. Among authors: lai l. Genome Biol. 2024 Apr 26;25(1):108. doi: 10.1186/s13059-024-03257-z. Genome Biol. 2024. PMID: 38671524 Free PMC article.
Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors.
Chen F, Lian M, Ma B, Gou S, Luo X, Yang K, Shi H, Xie J, Ge W, Ouyang Z, Lai C, Li N, Zhang Q, Jin Q, Liang Y, Chen T, Wang J, Zhao X, Li L, Yu M, Ye Y, Wang K, Wu H, Lai L. Chen F, et al. Among authors: lai c, lai l. Commun Biol. 2022 Nov 2;5(1):1163. doi: 10.1038/s42003-022-04152-8. Commun Biol. 2022. PMID: 36323848 Free PMC article.
Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing.
Wang K, Jin Q, Ruan D, Yang Y, Liu Q, Wu H, Zhou Z, Ouyang Z, Liu Z, Zhao Y, Zhao B, Zhang Q, Peng J, Lai C, Fan N, Liang Y, Lan T, Li N, Wang X, Wang X, Fan Y, Doevendans PA, Sluijter JPG, Liu P, Li X, Lai L. Wang K, et al. Among authors: lai c, lai l. Genome Res. 2017 Dec;27(12):2061-2071. doi: 10.1101/gr.222521.117. Epub 2017 Nov 16. Genome Res. 2017. PMID: 29146772 Free PMC article.
Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems.
Wu H, Liu Q, Shi H, Xie J, Zhang Q, Ouyang Z, Li N, Yang Y, Liu Z, Zhao Y, Lai C, Ruan D, Peng J, Ge W, Chen F, Fan N, Jin Q, Liang Y, Lan T, Yang X, Wang X, Lei Z, Doevendans PA, Sluijter JPG, Wang K, Li X, Lai L. Wu H, et al. Among authors: lai c, lai l. Cell Mol Life Sci. 2018 Oct;75(19):3593-3607. doi: 10.1007/s00018-018-2810-3. Epub 2018 Apr 10. Cell Mol Life Sci. 2018. PMID: 29637228 Free PMC article.
Efficient base editing for multiple genes and loci in pigs using base editors.
Xie J, Ge W, Li N, Liu Q, Chen F, Yang X, Huang X, Ouyang Z, Zhang Q, Zhao Y, Liu Z, Gou S, Wu H, Lai C, Fan N, Jin Q, Shi H, Liang Y, Lan T, Quan L, Li X, Wang K, Lai L. Xie J, et al. Among authors: lai c, lai l. Nat Commun. 2019 Jun 28;10(1):2852. doi: 10.1038/s41467-019-10421-8. Nat Commun. 2019. PMID: 31253764 Free PMC article.
CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I.
Li N, Gou S, Wang J, Zhang Q, Huang X, Xie J, Li L, Jin Q, Ouyang Z, Chen F, Ge W, Shi H, Liang Y, Zhuang Z, Zhao X, Lian M, Ye Y, Quan L, Wu H, Lai L, Wang K. Li N, et al. Among authors: lai l. Mol Ther. 2021 Mar 3;29(3):1001-1015. doi: 10.1016/j.ymthe.2020.11.023. Epub 2020 Nov 20. Mol Ther. 2021. PMID: 33221434 Free PMC article.
3,116 results