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AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model.
Niewiadomska-Cimicka A, Fievet L, Surdyka M, Jesion E, Keime C, Singer E, Eisenmann A, Kalinowska-Poska Z, Nguyen HHP, Fiszer A, Figiel M, Trottier Y. Niewiadomska-Cimicka A, et al. Among authors: fiszer a. Int J Mol Sci. 2024 Apr 15;25(8):4354. doi: 10.3390/ijms25084354. Int J Mol Sci. 2024. PMID: 38673939 Free PMC article.
Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models.
Joachimiak P, Ciesiołka A, Kozłowska E, Świtoński PM, Figura G, Ciołak A, Adamek G, Surdyka M, Kalinowska-Pośka Ż, Figiel M, Caron NS, Hayden MR, Fiszer A. Joachimiak P, et al. Among authors: fiszer a. BMC Biol. 2023 Feb 1;21(1):17. doi: 10.1186/s12915-023-01515-3. BMC Biol. 2023. PMID: 36726088 Free PMC article.
Mouse ataxin-3 functional knock-out model.
Switonski PM, Fiszer A, Kazmierska K, Kurpisz M, Krzyzosiak WJ, Figiel M. Switonski PM, et al. Among authors: fiszer a. Neuromolecular Med. 2011 Mar;13(1):54-65. doi: 10.1007/s12017-010-8137-3. Epub 2010 Oct 14. Neuromolecular Med. 2011. PMID: 20945165 Free PMC article.
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Jazurek-Ciesiolka M, Ciesiolka A, Komur AA, Urbanek-Trzeciak MO, Krzyzosiak WJ, Fiszer A. Jazurek-Ciesiolka M, et al. Among authors: fiszer a. J Mol Biol. 2020 Dec 4;432(24):166699. doi: 10.1016/j.jmb.2020.10.033. Epub 2020 Nov 4. J Mol Biol. 2020. PMID: 33157084 Free article.
Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts.
Ciesiolka A, Stroynowska-Czerwinska A, Joachimiak P, Ciolak A, Kozlowska E, Michalak M, Dabrowska M, Olejniczak M, Raczynska KD, Zielinska D, Wozna-Wysocka M, Krzyzosiak WJ, Fiszer A. Ciesiolka A, et al. Among authors: fiszer a. Cell Mol Life Sci. 2021 Feb;78(4):1577-1596. doi: 10.1007/s00018-020-03596-7. Epub 2020 Jul 21. Cell Mol Life Sci. 2021. PMID: 32696070 Free PMC article.
32 results