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126 results

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Validation of a Human Challenge Model Using an LT-Expressing Enterotoxigenic E. coli Strain (LSN03-016011) and Characterization of Potential Amelioration of Disease by an Investigational Oral Vaccine Candidate (VLA1701).
Talaat KR, Porter CK, Chakraborty S, Feijoo BL, Brubaker J, Adjoodani BM, DeNearing B, Prouty MG, Poole ST, Bourgeois AL, Billingsley M, Sack DA, Eder-Lingelbach S, Taucher C. Talaat KR, et al. Among authors: brubaker j. Microorganisms. 2024 Apr 3;12(4):727. doi: 10.3390/microorganisms12040727. Microorganisms. 2024. PMID: 38674674 Free PMC article.
Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial.
Talaat KR, Porter CK, Jaep KM, Duplessis CA, Gutierrez RL, Maciel M Jr, Adjoodani B, Feijoo B, Chakraborty S, Brubaker J, Trop SA, Riddle MS, Joseph SS, Bourgeois AL, Prouty MG. Talaat KR, et al. Among authors: brubaker j. PLoS One. 2020 Dec 2;15(12):e0239888. doi: 10.1371/journal.pone.0239888. eCollection 2020. PLoS One. 2020. PMID: 33264302 Free PMC article. Clinical Trial.
Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic Escherichia coli CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic E. coli H10407 in Healthy Adult Volunteers.
Gutiérrez RL, Porter CK, Harro C, Talaat K, Riddle MS, DeNearing B, Brubaker J, Maciel M Jr, Laird RM, Poole S, Chakraborty S, Maier N, Sack DA, Savarino SJ. Gutiérrez RL, et al. Among authors: brubaker j. Microorganisms. 2024 Jan 29;12(2):288. doi: 10.3390/microorganisms12020288. Microorganisms. 2024. PMID: 38399692 Free PMC article.
Rifaximin Fails to Prevent Campylobacteriosis in the Human Challenge Model: A Randomized, Double-Blind, Placebo-Controlled Trial.
Rimmer JE, Harro C, Sack DA, Talaat KR, Gutierrez RL, DeNearing B, Brubaker J, Laird RM, Poly F, Maue AC, Jaep K, Alcala A, Mochalova Y, Gariepy CL, Chakraborty S, Guerry P, Tribble DR, Porter CK, Riddle MS. Rimmer JE, et al. Among authors: brubaker j. Clin Infect Dis. 2018 Apr 17;66(9):1435-1441. doi: 10.1093/cid/cix1014. Clin Infect Dis. 2018. PMID: 29145631 Clinical Trial.
Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.
Chakraborty S, Harro C, DeNearing B, Brubaker J, Connor S, Maier N, Dally L, Flores J, Bourgeois AL, Walker R, Sack DA. Chakraborty S, et al. Among authors: brubaker j. PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006442. doi: 10.1371/journal.pntd.0006442. eCollection 2018 Apr. PLoS Negl Trop Dis. 2018. PMID: 29702652 Free PMC article. Clinical Trial.
Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development.
Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM. Chakraborty S, et al. Among authors: brubaker j. J Infect Dis. 2018 Sep 22;218(9):1436-1446. doi: 10.1093/infdis/jiy312. J Infect Dis. 2018. PMID: 29800314 Free PMC article.
Enterotoxigenic E. coli virulence gene regulation in human infections.
Crofts AA, Giovanetti SM, Rubin EJ, Poly FM, Gutiérrez RL, Talaat KR, Porter CK, Riddle MS, DeNearing B, Brubaker J, Maciel M Jr, Alcala AN, Chakraborty S, Prouty MG, Savarino SJ, Davies BW, Trent MS. Crofts AA, et al. Among authors: brubaker j. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8968-E8976. doi: 10.1073/pnas.1808982115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30126994 Free PMC article. Clinical Trial.
Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge.
Harro C, Louis Bourgeois A, Sack D, Walker R, DeNearing B, Brubaker J, Maier N, Fix A, Dally L, Chakraborty S, Clements JD, Saunders I, Darsley MJ. Harro C, et al. Among authors: brubaker j. Vaccine. 2019 Mar 28;37(14):1978-1986. doi: 10.1016/j.vaccine.2019.02.025. Epub 2019 Feb 21. Vaccine. 2019. PMID: 30797634 Free PMC article.
Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea.
Talaat KR, Porter CK, Bourgeois AL, Lee TK, Duplessis CA, Maciel M Jr, Gutierrez RL, DeNearing B, Adjoodani B, Adkinson R, Testa KJ, Feijoo B, Alcala AN, Brubaker J, Beselman A, Chakraborty S, Sack D, Halpern J, Trop S, Wu H, Jiao J, Sullivan E, Riddle MS, Joseph SS, Poole ST, Prouty MG. Talaat KR, et al. Among authors: brubaker j. Gut Microbes. 2020 Nov 9;12(1):1732852. doi: 10.1080/19490976.2020.1732852. Epub 2020 Mar 13. Gut Microbes. 2020. PMID: 32167011 Free PMC article. Clinical Trial.
126 results