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Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants.
Thümmler L, Beckmann N, Sehl C, Soddemann M, Braß P, Bormann M, Brochhagen L, Elsner C, Hoertel N, Cougoule C, Ciesek S, Widera M, Dittmer U, Lindemann M, Horn PA, Witzke O, Kadow S, Kamler M, Gulbins E, Becker KA, Krawczyk A. Thümmler L, et al. Among authors: soddemann m. Viruses. 2024 Mar 30;16(4):545. doi: 10.3390/v16040545. Viruses. 2024. PMID: 38675888 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: soddemann m. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. Among authors: soddemann m. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Sphingosine Prevents Rhinoviral Infections.
Lang J, Soddemann M, Edwards MJ, Wilson GC, Lang KS, Gulbins E. Lang J, et al. Among authors: soddemann m. Int J Mol Sci. 2024 Feb 20;25(5):2486. doi: 10.3390/ijms25052486. Int J Mol Sci. 2024. PMID: 38473734 Free PMC article.
Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.
Becker KA, Fahsel B, Kemper H, Mayeres J, Li C, Wilker B, Keitsch S, Soddemann M, Sehl C, Kohnen M, Edwards MJ, Grassmé H, Caldwell CC, Seitz A, Fraunholz M, Gulbins E. Becker KA, et al. Among authors: soddemann m. Infect Immun. 2017 Dec 19;86(1):e00606-17. doi: 10.1128/IAI.00606-17. Print 2018 Jan. Infect Immun. 2017. PMID: 29084896 Free PMC article.
Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.
Carstens H, Kalka K, Verhaegh R, Schumacher F, Soddemann M, Wilker B, Keitsch S, Sehl C, Kleuser B, Hübler M, Rauen U, Becker AK, Koch A, Gulbins E, Kamler M. Carstens H, et al. Among authors: soddemann m. PLoS One. 2022 Jul 21;17(7):e0271620. doi: 10.1371/journal.pone.0271620. eCollection 2022. PLoS One. 2022. PMID: 35862397 Free PMC article.
32 results