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Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer.
Raymant M, Astuti Y, Alvaro-Espinosa L, Green D, Quaranta V, Bellomo G, Glenn M, Chandran-Gorner V, Palmer DH, Halloran C, Ghaneh P, Henderson NC, Morton JP, Valiente M, Mielgo A, Schmid MC. Raymant M, et al. Among authors: mielgo a. Nat Commun. 2024 Apr 27;15(1):3593. doi: 10.1038/s41467-024-47949-3. Nat Commun. 2024. PMID: 38678021 Free PMC article.
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.
Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, Engle D, Campbell F, Palmer D, Ko JH, Tuveson DA, Hirsch E, Mielgo A, Schmid MC. Nielsen SR, et al. Among authors: mielgo a. Nat Cell Biol. 2016 May;18(5):549-60. doi: 10.1038/ncb3340. Epub 2016 Apr 18. Nat Cell Biol. 2016. PMID: 27088855 Free PMC article.
Liver Tropism in Cancer: The Hepatic Metastatic Niche.
Mielgo A, Schmid MC. Mielgo A, et al. Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a037259. doi: 10.1101/cshperspect.a037259. Cold Spring Harb Perspect Med. 2020. PMID: 31548227 Free PMC article. Review.
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis.
Bellomo G, Rainer C, Quaranta V, Astuti Y, Raymant M, Boyd E, Stafferton R, Campbell F, Ghaneh P, Halloran CM, Hammond DE, Morton JP, Palmer D, Vimalachandran D, Jones R, Mielgo A, Schmid MC. Bellomo G, et al. Among authors: mielgo a. Gut. 2022 Nov;71(11):2284-2299. doi: 10.1136/gutjnl-2021-325272. Epub 2022 Jan 12. Gut. 2022. PMID: 35022267 Free PMC article.
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors.
Ireland L, Santos A, Ahmed MS, Rainer C, Nielsen SR, Quaranta V, Weyer-Czernilofsky U, Engle DD, Perez-Mancera PA, Coupland SE, Taktak A, Bogenrieder T, Tuveson DA, Campbell F, Schmid MC, Mielgo A. Ireland L, et al. Among authors: mielgo a. Cancer Res. 2016 Dec 1;76(23):6851-6863. doi: 10.1158/0008-5472.CAN-16-1201. Epub 2016 Oct 14. Cancer Res. 2016. PMID: 27742686 Free PMC article.
62 results