Dunford J - Search Results

1

The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms.

Chang CH, Liu F, Militi S, Hester S, Nibhani R, Deng S, Dunford J, Rendek A, Soonawalla Z, Fischer R, Oppermann U, Pauklin S. Chang CH, et al. Among authors: dunford j. Nat Commun. 2024 Apr 27;15(1):3580. doi: 10.1038/s41467-024-47680-z. Nat Commun. 2024. PMID: 38678032 Free PMC article.

2

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.

Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs AP, Philpott M, Uyulur F, Morova T, Dunford JE, Göklemez S, Arı Ş, Oppermann U, Önder TT. Ebrahimi A, et al. Nat Chem Biol. 2019 May;15(5):519-528. doi: 10.1038/s41589-019-0264-z. Epub 2019 Apr 8. Nat Chem Biol. 2019. PMID: 30962627 Free PMC article.

3

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

Kavanagh KL, Dunford JE, Bunkoczi G, Russell RGG, Oppermann U. Kavanagh KL, et al. J Biol Chem. 2006 Aug 4;281(31):22004-22012. doi: 10.1074/jbc.M602603200. Epub 2006 May 11. J Biol Chem. 2006. PMID: 16698791 Free article.

4

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.

Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford JE, Nibhani R, Philpott M, Malzahn J, Wells G, Faram R, Cribbs AP, Halidi N, Li F, Chau I, Greschik H, Velupillai S, Allali-Hassani A, Bennett J, Christott T, Giroud C, Lewis AM, Huber KVM, Athanasou N, Bountra C, Jung M, Schüle R, Vedadi M, Arrowsmith C, Xiong Y, Jin J, Fedorov O, Farnie G, Brennan PE, Oppermann U. Fagan V, et al. Among authors: dunford je. J Med Chem. 2019 Oct 24;62(20):9008-9025. doi: 10.1021/acs.jmedchem.9b00562. Epub 2019 Oct 15. J Med Chem. 2019. PMID: 31550156

5

HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta.

Dickson A, Yutuc E, Thornton CA, Dunford JE, Oppermann U, Wang Y, Griffiths WJ. Dickson A, et al. Among authors: dunford je. Open Biol. 2023 May;13(5):220313. doi: 10.1098/rsob.220313. Epub 2023 May 3. Open Biol. 2023. PMID: 37132223 Free PMC article.

6

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, Oppermann U, Penning TM, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. J Steroid Biochem Mol Biol. 2019 May;189:218-227. doi: 10.1016/j.jsbmb.2019.02.002. Epub 2019 Feb 12. J Steroid Biochem Mol Biol. 2019. PMID: 30769091 Free PMC article.

7

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL. Dunford JE, et al. J Med Chem. 2008 Apr 10;51(7):2187-95. doi: 10.1021/jm7015733. Epub 2008 Mar 8. J Med Chem. 2008. PMID: 18327899

8

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma.

Ozyerli-Goknar E, Sur-Erdem I, Seker F, Cingöz A, Kayabolen A, Kahya-Yesil Z, Uyulur F, Gezen M, Tolay N, Erman B, Gönen M, Dunford J, Oppermann U, Bagci-Onder T. Ozyerli-Goknar E, et al. Among authors: dunford j. Cell Death Dis. 2019 Nov 26;10(12):894. doi: 10.1038/s41419-019-2107-y. Cell Death Dis. 2019. PMID: 31772153 Free PMC article.

9

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U. Kavanagh KL, et al. Among authors: dunford je. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. doi: 10.1073/pnas.0601643103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684881 Free PMC article.

10

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Russell RG, et al. Among authors: dunford je. Ann N Y Acad Sci. 2007 Nov;1117:209-57. doi: 10.1196/annals.1402.089. Ann N Y Acad Sci. 2007. PMID: 18056045 Review.

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