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A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models.
Campos HM, Pereira RM, de Oliveira Ferreira PY, Uchenna N, Branco da Silva CR, Pruccoli L, Sanz G, Rodrigues MF, Vaz BG, Rivello BG, Batista da Rocha AL, de Carvalho FS, Oliveira GAR, Lião LM, Georg RC, Leite JA, Dos Santos FCA, Costa EA, Menegatti R, Tarozzi A, Ghedini PC. Campos HM, et al. Among authors: ghedini pc. Chem Biol Interact. 2024 May 25;395:111026. doi: 10.1016/j.cbi.2024.111026. Epub 2024 Apr 26. Chem Biol Interact. 2024. PMID: 38679115
LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes.
Moreira LKDS, Turones LC, Campos HM, Nazareth AM, Thomaz DV, Gil ES, Ghedini PC, Rocha FFD, Menegatti R, Fajemiroye JO, Costa EA. Moreira LKDS, et al. Among authors: ghedini pc. Life Sci. 2023 Jan 1;312:121199. doi: 10.1016/j.lfs.2022.121199. Epub 2022 Nov 17. Life Sci. 2023. PMID: 36402170 Free article.
Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice.
Okoh VI, Campos HM, Yasmin de Oliveira Ferreira P, Pereira RM, Souza Silva Y, Arruda EL, Pagliarani B, de Almeida Ribeiro Oliveira G, Lião LM, Franco Dos Santos G, Vaz BG, Sabino JR, Alcantara Dos Santos FC, Costa EA, Tarozzi A, Menegatti R, Ghedini PC. Okoh VI, et al. Among authors: ghedini pc. J Pharm Pharmacol. 2024 Apr 3;76(4):368-380. doi: 10.1093/jpp/rgae011. J Pharm Pharmacol. 2024. PMID: 38330395
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Among authors: ghedini pc. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291.
Turones LC, Machado LS, Vaz BG, de Almeida R Oliveira G, da Silva Moreira LK, Almeida DS, Martins AN, Fajemiroye JO, Martins JLR, Ghedini PC, Campos HM, Dos Santos FCA, da Silva CRB, Lião LM, Gil ES, Costa EA, Menegatti R. Turones LC, et al. Among authors: ghedini pc. Inflammopharmacology. 2023 Oct;31(5):2451-2465. doi: 10.1007/s10787-023-01324-8. Epub 2023 Sep 4. Inflammopharmacology. 2023. PMID: 37667090
Anxiolytic-like effect of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways.
Brito AF, Fajemiroye JO, Neri HFS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Ghedini PC, Lião LM, Menegatti R, Costa EA. Brito AF, et al. Among authors: ghedini pc. Chem Biol Drug Des. 2017 Sep;90(3):432-442. doi: 10.1111/cbdd.12961. Epub 2017 Mar 6. Chem Biol Drug Des. 2017. PMID: 28160425
New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities.
de Oliveira LP, da Silva DP, Florentino IF, Fajemiroye JO, de Oliveira TS, Marcelino RI, Pazini F, Lião LM, Ghedini PC, de Moura SS, Valadares MC, de Carvalho VV, Vaz BG, Menegatti R, Costa EA. de Oliveira LP, et al. Among authors: ghedini pc. Chem Biol Drug Des. 2017 Jan;89(1):124-135. doi: 10.1111/cbdd.12838. Epub 2016 Sep 14. Chem Biol Drug Des. 2017. PMID: 27526659
56 results