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A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3- nitropropionic acid in in vitro and in vivo models.
Campos HM, Pereira RM, de Oliveira Ferreira PY, Uchenna N, Branco da Silva CR, Pruccoli L, Sanz G, Rodrigues MF, Vaz BG, Rivello BG, Batista da Rocha AL, de Carvalho FS, Oliveira GAR, Lião LM, Georg RC, Leite JA, Dos Santos FCA, Costa EA, Menegatti R, Tarozzi A, Ghedini PC. Campos HM, et al. Among authors: menegatti r. Chem Biol Interact. 2024 May 25;395:111026. doi: 10.1016/j.cbi.2024.111026. Epub 2024 Apr 26. Chem Biol Interact. 2024. PMID: 38679115
LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes.
Moreira LKDS, Turones LC, Campos HM, Nazareth AM, Thomaz DV, Gil ES, Ghedini PC, Rocha FFD, Menegatti R, Fajemiroye JO, Costa EA. Moreira LKDS, et al. Among authors: menegatti r. Life Sci. 2023 Jan 1;312:121199. doi: 10.1016/j.lfs.2022.121199. Epub 2022 Nov 17. Life Sci. 2023. PMID: 36402170 Free article.
Chrysin bonded to β-d-glucose tetraacetate enhances its protective effects against the neurotoxicity induced by aluminum in Swiss mice.
Okoh VI, Campos HM, Yasmin de Oliveira Ferreira P, Pereira RM, Souza Silva Y, Arruda EL, Pagliarani B, de Almeida Ribeiro Oliveira G, Lião LM, Franco Dos Santos G, Vaz BG, Sabino JR, Alcantara Dos Santos FC, Costa EA, Tarozzi A, Menegatti R, Ghedini PC. Okoh VI, et al. Among authors: menegatti r. J Pharm Pharmacol. 2024 Apr 3;76(4):368-380. doi: 10.1093/jpp/rgae011. J Pharm Pharmacol. 2024. PMID: 38330395
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Among authors: menegatti r. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)- New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system.
da Silva DM, Sanz G, Vaz BG, de Carvalho FS, Lião LM, de Oliveira DR, Moreira LKDS, Cardoso CS, de Brito AF, da Silva DPB, da Rocha FF, Santana IGC, Galdino PM, Costa EA, Menegatti R. da Silva DM, et al. Among authors: menegatti r. Biomed Pharmacother. 2018 Jul;103:546-552. doi: 10.1016/j.biopha.2018.04.077. Epub 2018 Apr 24. Biomed Pharmacother. 2018. PMID: 29677541
Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1- Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated by Serotonergic and GABAergic Pathways.
Almeida LS, Santana IGC, da Silva Moreira LK, Turones LC, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Menegatti R, Costa EA, de Brito AF. Almeida LS, et al. Among authors: menegatti r. CNS Neurol Disord Drug Targets. 2022;21(6):520-532. doi: 10.2174/1871527320666211112173233. CNS Neurol Disord Drug Targets. 2022. PMID: 34781873
85 results