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A chimeric adenovirus-vectored vaccine based on Beta spike and Delta RBD confers a broad-spectrum neutralization against Omicron-included SARS-CoV-2 variants.
Hong W, Lei H, Peng D, Huang Y, He C, Yang J, Zhou Y, Liu J, Pan X, Que H, Alu A, Chen L, Ai J, Qin F, Wang B, Ao D, Zeng Z, Hao Y, Zhang Y, Huang X, Ye C, Fu M, He X, Bi Z, Han X, Luo M, Hu H, Cheng W, Dong H, Lei J, Chen L, Zhou X, Wang W, Lu G, Shen G, Yang L, Yang J, Li J, Wang Z, Song X, Sun Q, Lu S, Wang Y, Cheng P, Wei X. Hong W, et al. Among authors: wang w, wang z, wang y, wang b. MedComm (2020). 2024 Apr 27;5(5):e539. doi: 10.1002/mco2.539. eCollection 2024 May. MedComm (2020). 2024. PMID: 38680520 Free PMC article.
Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5-included SARS-CoV-2 variants than homologous vaccination of mRNA vaccine.
Peng D, Zhao T, Hong W, Fu M, He C, Chen L, Ren W, Lei H, Yang J, Alu A, Ni Y, Liu J, Li J, Wang W, Shen G, Zhao Z, Yang L, Yang J, Wang Z, Tanaka Y, Lu G, Song X, Wei X. Peng D, et al. Among authors: wang w, wang z. MedComm (2020). 2023 Mar 10;4(2):e238. doi: 10.1002/mco2.238. eCollection 2023 Apr. MedComm (2020). 2023. PMID: 36911160 Free PMC article.
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
Yang J, Wang W, Chen Z, Lu S, Yang F, Bi Z, Bao L, Mo F, Li X, Huang Y, Hong W, Yang Y, Zhao Y, Ye F, Lin S, Deng W, Chen H, Lei H, Zhang Z, Luo M, Gao H, Zheng Y, Gong Y, Jiang X, Xu Y, Lv Q, Li D, Wang M, Li F, Wang S, Wang G, Yu P, Qu Y, Yang L, Deng H, Tong A, Li J, Wang Z, Yang J, Shen G, Zhao Z, Li Y, Luo J, Liu H, Yu W, Yang M, Xu J, Wang J, Li H, Wang H, Kuang D, Lin P, Hu Z, Guo W, Cheng W, He Y, Song X, Chen C, Xue Z, Yao S, Chen L, Ma X, Chen S, Gou M, Huang W, Wang Y, Fan C, Tian Z, Shi M, Wang FS, Dai L, Wu M, Li G, Wang G, Peng Y, Qian Z, Huang C, Lau JY, Yang Z, Wei Y, Cen X, Peng X, Qin C, Zhang K, Lu G, Wei X. Yang J, et al. Among authors: wang h, wang w, wang g, wang fs, wang z, wang j, wang y, wang m, wang s. Nature. 2020 Oct;586(7830):572-577. doi: 10.1038/s41586-020-2599-8. Epub 2020 Jul 29. Nature. 2020. PMID: 32726802
Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2.
Lei H, Alu A, Yang J, He C, Hong W, Cheng Z, Yang L, Li J, Wang Z, Wang W, Lu G, Wei X. Lei H, et al. Among authors: wang w, wang z. Signal Transduct Target Ther. 2020 Dec 11;5(1):291. doi: 10.1038/s41392-020-00434-x. Signal Transduct Target Ther. 2020. PMID: 33311439 Free PMC article. No abstract available.
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells.
Hong W, Yang J, Zou J, Bi Z, He C, Lei H, He X, Li X, Alu A, Ren W, Wang Z, Jiang X, Zhong K, Jia G, Yang Y, Yu W, Huang Q, Yang M, Zhou Y, Zhao Y, Kuang D, Wang J, Wang H, Chen S, Luo M, Zhang Z, Lu T, Chen L, Que H, He Z, Sun Q, Wang W, Shen G, Lu G, Zhao Z, Yang L, Yang J, Wang Z, Li J, Song X, Dai L, Chen C, Geng J, Gou M, Chen L, Dong H, Peng Y, Huang C, Qian Z, Cheng W, Fan C, Wei Y, Su Z, Tong A, Lu S, Peng X, Wei X. Hong W, et al. Among authors: wang h, wang w, wang z, wang j. Cell Mol Immunol. 2022 May;19(5):577-587. doi: 10.1038/s41423-022-00845-6. Epub 2022 Mar 10. Cell Mol Immunol. 2022. PMID: 35273357 Free PMC article.
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant.
He C, Yang J, Hong W, Chen Z, Peng D, Lei H, Alu A, He X, Bi Z, Jiang X, Jia G, Yang Y, Zhou Y, Yu W, Tang C, Huang Q, Yang M, Li B, Li J, Wang J, Que H, Chen L, Ren W, Wan D, Li J, Wang W, Shen G, Zhao Z, Yang L, Yang J, Wang Z, Su Z, Wei Y, Cen X, Tanaka Y, Song X, Lu S, Peng X, Lu G, Wei X. He C, et al. Among authors: wang w, wang j, wang z. Nat Commun. 2022 Sep 17;13(1):5459. doi: 10.1038/s41467-022-33209-9. Nat Commun. 2022. PMID: 36115859 Free PMC article.
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection.
Yang J, Hong W, Lei H, He C, Lei W, Zhou Y, Zhao T, Alu A, Ma X, Li J, Yang L, Wang Z, Wang W, Lu G, Shen G, Lu S, Wu G, Shi H, Wei X. Yang J, et al. Among authors: wang w, wang z. Signal Transduct Target Ther. 2023 Jun 19;8(1):252. doi: 10.1038/s41392-023-01495-4. Signal Transduct Target Ther. 2023. PMID: 37336889 Free PMC article.
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