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The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J. Pelletier JP, et al. Among authors: geng c. Arthritis Res Ther. 2005;7(5):R1091-102. doi: 10.1186/ar1788. Epub 2005 Jul 19. Arthritis Res Ther. 2005. PMID: 16207326 Free PMC article.
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
Tardif G, Dupuis M, Reboul P, Geng CS, Pelletier JP, Ranger P, Martel-Pelletier J. Tardif G, et al. Among authors: geng cs. Osteoarthritis Cartilage. 2003 Jul;11(7):524-37. doi: 10.1016/s1063-4584(03)00079-7. Osteoarthritis Cartilage. 2003. PMID: 12814616 Free article.
1,505 results