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Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.
van Zaanen HC, Koopmans RP, Aarden LA, Rensink HJ, Stouthard JM, Warnaar SO, Lokhorst HM, van Oers MH. van Zaanen HC, et al. Among authors: lokhorst hm. J Clin Invest. 1996 Sep 15;98(6):1441-8. doi: 10.1172/JCI118932. J Clin Invest. 1996. PMID: 8823310 Free PMC article. Clinical Trial.
Induction therapy with vincristine, adriamycin, dexamethasone (VAD) and intermediate-dose melphalan (IDM) followed by autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma.
Lokhorst HM, Sonneveld P, Cornelissen JJ, Joosten P, van Marwijk Kooy M, Meinema J, Nieuwenhuis HK, van Oers MH, Richel DJ, Segeren CN, Veth G, Verdonck LF, Wijermans PW. Lokhorst HM, et al. Bone Marrow Transplant. 1999 Feb;23(4):317-22. doi: 10.1038/sj.bmt.1701574. Bone Marrow Transplant. 1999. PMID: 10100574 Clinical Trial.
A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma.
Lokhorst HM, van der Holt B, Zweegman S, Vellenga E, Croockewit S, van Oers MH, von dem Borne P, Wijermans P, Schaafsma R, de Weerdt O, Wittebol S, Delforge M, Berenschot H, Bos GM, Jie KS, Sinnige H, van Marwijk-Kooy M, Joosten P, Minnema MC, van Ammerlaan R, Sonneveld P; Dutch-Belgian Hemato-Oncology Group (HOVON). Lokhorst HM, et al. Blood. 2010 Feb 11;115(6):1113-20. doi: 10.1182/blood-2009-05-222539. Epub 2009 Oct 30. Blood. 2010. PMID: 19880501 Free article. Clinical Trial.
Partially T-cell-depleted allogeneic stem-cell transplantation for first-line treatment of multiple myeloma: a prospective evaluation of patients treated in the phase III study HOVON 24 MM.
Lokhorst HM, Segeren CM, Verdonck LF, van der Holt B, Raymakers R, van Oers MH, Barge RM, Schouten HC, Westveer PH, Steijaert MM, Cornelissen JJ, Sonneveld P; Dutch-Belgian Hemato-Oncology Cooperative Group. Lokhorst HM, et al. J Clin Oncol. 2003 May 1;21(9):1728-33. doi: 10.1200/JCO.2003.04.033. J Clin Oncol. 2003. PMID: 12721248 Clinical Trial.
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
Derksen PW, Tjin E, Meijer HP, Klok MD, MacGillavry HD, van Oers MH, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren M, Pals ST. Derksen PW, et al. Among authors: lokhorst hm. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6122-7. doi: 10.1073/pnas.0305855101. Epub 2004 Apr 5. Proc Natl Acad Sci U S A. 2004. PMID: 15067127 Free PMC article.
243 results