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Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.
Billheimer JT, Dicker IB, Wynn R, Bradley JD, Cromley DA, Godonis HE, Grimminger LC, He B, Kieras CJ, Pedicord DL, Spitz SM, Thomas BE, Zolotarjova NI, Gorko MA, Hollis GF, Daly RN, Stern AM, Seiffert D. Billheimer JT, et al. Blood. 2002 May 15;99(10):3540-6. doi: 10.1182/blood.v99.10.3540. Blood. 2002. PMID: 11986205 Free article.
Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia.
Seiffert D, Stern AM, Ebling W, Rossi RJ, Barrett YC, Wynn R, Hollis GF, He B, Kieras CJ, Pedicord DL, Cromley DA, Hua TA, Stein RB, Daly RN, Sferruzza A, Pieniaszek HJ, Billheimer JT. Seiffert D, et al. Among authors: billheimer jt. Blood. 2003 Jan 1;101(1):58-63. doi: 10.1182/blood-2002-02-0471. Epub 2002 Jun 28. Blood. 2003. PMID: 12393571 Free article. Clinical Trial.
Large-scale purification of active platelet integrin glycoprotein IIb-IIIa.
Hillman MC, Zolotarjova NI, Patrick DR, McCabe DD, Shen K, Corman JI, Billheimer JT, Seiffert DA, Hollis GF, Wynn R. Hillman MC, et al. Among authors: billheimer jt. Protein Expr Purif. 2002 Aug;25(3):494-502. doi: 10.1016/s1046-5928(02)00027-x. Protein Expr Purif. 2002. PMID: 12182831
140 results