Lock EA - Search Results

1

From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug.

Lock EA, Ellis MK, Gaskin P, Robinson M, Auton TR, Provan WM, Smith LL, Prisbylla MP, Mutter LC, Lee DL. Lock EA, et al. J Inherit Metab Dis. 1998 Aug;21(5):498-506. doi: 10.1023/a:1005458703363. J Inherit Metab Dis. 1998. PMID: 9728330 Review.

2

The role of mode of action studies in extrapolating to human risks in toxicology.

Lock EA, Smith LL. Lock EA, et al. Toxicol Lett. 2003 Apr 11;140-141:317-22. doi: 10.1016/s0378-4274(03)00028-6. Toxicol Lett. 2003. PMID: 12676480 Review.

3

Tyrosinemia produced by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) in experimental animals and its relationship to corneal injury.

Lock EA, Gaskin P, Ellis M, Provan WM, Smith LL. Lock EA, et al. Toxicol Appl Pharmacol. 2006 Aug 15;215(1):9-16. doi: 10.1016/j.taap.2006.01.015. Epub 2006 Mar 31. Toxicol Appl Pharmacol. 2006. PMID: 16580702

4

Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione.

Ellis MK, Whitfield AC, Gowans LA, Auton TR, Provan WM, Lock EA, Smith LL. Ellis MK, et al. Among authors: lock ea. Toxicol Appl Pharmacol. 1995 Jul;133(1):12-9. doi: 10.1006/taap.1995.1121. Toxicol Appl Pharmacol. 1995. PMID: 7597701

5

Characterization of the interaction of 2-[2-nitro-4-(trifluoromethyl)benzoyl]-4,4,6,6,-tetramethyl- cyclohexane-1,3,5-trione with rat hepatic 4-hydroxyphenylpyruvate dioxygenase.

Ellis MK, Whitfield AC, Gowans LA, Auton TR, Provan WM, Lock EA, Lee DL, Smith LL. Ellis MK, et al. Among authors: lock ea. Chem Res Toxicol. 1996 Jan-Feb;9(1):24-27. doi: 10.1021/tx950100w. Chem Res Toxicol. 1996. PMID: 8924597

6

Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1-3-dione (NTBC): effect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat.

Lock EA, Gaskin P, Ellis MK, Provan WM, Robinson M, Smith LL, Prisbylla MP, Mutter LC. Lock EA, et al. Toxicol Appl Pharmacol. 1996 Dec;141(2):439-47. doi: 10.1006/taap.1996.0310. Toxicol Appl Pharmacol. 1996. PMID: 8975769

7

The effect of a low-protein diet and dietary supplementation of threonine on tyrosine and 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione-induced corneal lesions, the extent of tyrosinemia, and the activity of enzymes involved in tyrosine catabolism in the rat.

Lock EA, Gaskin P, Ellis MK, Robinson M, Provan WM, Smith LL. Lock EA, et al. Toxicol Appl Pharmacol. 1998 May;150(1):125-32. doi: 10.1006/taap.1998.8404. Toxicol Appl Pharmacol. 1998. PMID: 9630461

8

Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) and its effect on enzymes involved in tyrosine catabolism in the mouse.

Lock EA, Gaskin P, Ellis MK, McLean Provan W, Robinson M, Smith LL. Lock EA, et al. Toxicology. 2000 Apr 3;144(1-3):179-87. doi: 10.1016/s0300-483x(99)00205-x. Toxicology. 2000. PMID: 10781886

9

Further evidence that the blood/brain barrier impedes paraquat entry into the brain.

Naylor JL, Widdowson PS, Simpson MG, Farnworth M, Ellis MK, Lock EA. Naylor JL, et al. Among authors: lock ea. Hum Exp Toxicol. 1995 Jul;14(7):587-94. doi: 10.1177/096032719501400706. Hum Exp Toxicol. 1995. PMID: 7576819

10

Inhibition of paraquat accumulation in rat lung slices by a component of rat plasma and a variety of drugs and endogenous amines.

Lock EA, Smith LL, Rose MS. Lock EA, et al. Biochem Pharmacol. 1976 Aug 1;25(15):1769-72. doi: 10.1016/0006-2952(76)90413-5. Biochem Pharmacol. 1976. PMID: 942480 No abstract available.

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