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From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug.
Lock EA, Ellis MK, Gaskin P, Robinson M, Auton TR, Provan WM, Smith LL, Prisbylla MP, Mutter LC, Lee DL. Lock EA, et al. Among authors: provan wm. J Inherit Metab Dis. 1998 Aug;21(5):498-506. doi: 10.1023/a:1005458703363. J Inherit Metab Dis. 1998. PMID: 9728330 Review.
The effect of a low-protein diet and dietary supplementation of threonine on tyrosine and 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione-induced corneal lesions, the extent of tyrosinemia, and the activity of enzymes involved in tyrosine catabolism in the rat.
Lock EA, Gaskin P, Ellis MK, Robinson M, Provan WM, Smith LL. Lock EA, et al. Among authors: provan wm. Toxicol Appl Pharmacol. 1998 May;150(1):125-32. doi: 10.1006/taap.1998.8404. Toxicol Appl Pharmacol. 1998. PMID: 9630461
Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers.
Hall MG, Wilks MF, Provan WM, Eksborg S, Lumholtz B. Hall MG, et al. Among authors: provan wm. Br J Clin Pharmacol. 2001 Aug;52(2):169-77. doi: 10.1046/j.0306-5251.2001.01421.x. Br J Clin Pharmacol. 2001. PMID: 11488774 Free PMC article. Clinical Trial.
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