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Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.
Shepherd TA, Aikins JA, Bleakman D, Cantrell BE, Rearick JP, Simon RL, Smith EC, Stephenson GA, Zimmerman DM, Mandelzys A, Jarvie KR, Ho K, Deverill M, Kamboj RK. Shepherd TA, et al. Among authors: smith ec. J Med Chem. 2002 May 9;45(10):2101-11. doi: 10.1021/jm0105474. J Med Chem. 2002. PMID: 11985477
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson T Jr, Herron DK, Li HY, McMillen WT, Mort N, Parsons S, Smith EC, Wagner JR, Yan L, Zhang F, Yingling JM. Sawyer JS, et al. Among authors: smith ec. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3581-4. doi: 10.1016/j.bmcl.2004.04.007. Bioorg Med Chem Lett. 2004. PMID: 15177479
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK, Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S, Smith EC, Vieth M, Weir LC, Yan L, Zhang F, Yingling JM. Sawyer JS, et al. Among authors: smith ec. J Med Chem. 2003 Sep 11;46(19):3953-6. doi: 10.1021/jm0205705. J Med Chem. 2003. PMID: 12954047
Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2.
Sawyer JS, Beight DW, Smith EC, Snyder DW, Chastain MK, Tielking RL, Hartley LW, Carlson DG. Sawyer JS, et al. Among authors: smith ec. J Med Chem. 2005 Feb 10;48(3):893-6. doi: 10.1021/jm0401309. J Med Chem. 2005. PMID: 15689175
Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.
Meanwell NA, Pearce BC, Roth HR, Smith EC, Wedding DL, Wright JJ, Buchanan JO, Baryla UM, Gamberdella M, Gillespie E, et al. Meanwell NA, et al. Among authors: smith ec. J Med Chem. 1992 Jul 10;35(14):2672-87. doi: 10.1021/jm00092a019. J Med Chem. 1992. PMID: 1321910
395 results