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Year Number of Results
2014 1
2015 8
2016 1
2017 2
2019 3
2020 4
2021 1
2022 1
2024 0

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20 results

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Page 1
Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model.
Kumar S, Schoonderwoerd MJA, Kroonen JS, de Graaf IJ, Sluijter M, Ruano D, González-Prieto R, Verlaan-de Vries M, Rip J, Arens R, de Miranda NFCC, Hawinkels LJAC, van Hall T, Vertegaal ACO. Kumar S, et al. Gut. 2022 Nov;71(11):2266-2283. doi: 10.1136/gutjnl-2021-324834. Epub 2022 Jan 24. Gut. 2022. PMID: 35074907 Free PMC article.
Mapping the SUMOylated landscape.
Eifler K, Vertegaal AC. Eifler K, et al. FEBS J. 2015 Oct;282(19):3669-80. doi: 10.1111/febs.13378. Epub 2015 Jul 31. FEBS J. 2015. PMID: 26185901 Free PMC article. Review.
ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients.
Apelt K, White SM, Kim HS, Yeo JE, Kragten A, Wondergem AP, Rooimans MA, González-Prieto R, Wiegant WW, Lunke S, Flanagan D, Pantaleo S, Quinlan C, Hardikar W, van Attikum H, Vertegaal ACO, Wilson BT, Wolthuis RMF, Schärer OD, Luijsterburg MS. Apelt K, et al. J Exp Med. 2021 Mar 1;218(3):e20200622. doi: 10.1084/jem.20200622. J Exp Med. 2021. PMID: 33315086 Free PMC article.
USP7: combining tools towards selectivity.
Gjonaj L , Sapmaz A , González-Prieto R , Vertegaal ACO , Flierman D , Ovaa H . Gjonaj L , et al. Chem Commun (Camb). 2019 Apr 25;55(35):5075-5078. doi: 10.1039/c9cc00969h. Chem Commun (Camb). 2019. PMID: 30972393
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. Mulder MP, et al. Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182664 Free PMC article.
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.
Liu S, González-Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P. Liu S, et al. Clin Cancer Res. 2020 Mar 15;26(6):1460-1473. doi: 10.1158/1078-0432.CCR-19-1373. Epub 2019 Dec 19. Clin Cancer Res. 2020. PMID: 31857432 Free PMC article.
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.
Helfricht A, Thijssen PE, Rother MB, Shah RG, Du L, Takada S, Rogier M, Moritz J, IJspeert H, Stoepker C, van Ostaijen-Ten Dam MM, Heyer V, Luijsterburg MS, de Groot A, Jak R, Grootaers G, Wang J, Rao P, Vertegaal ACO, van Tol MJD, Pan-Hammarström Q, Reina-San-Martin B, Shah GM, van der Burg M, van der Maarel SM, van Attikum H. Helfricht A, et al. J Exp Med. 2020 Nov 2;217(11):e20191688. doi: 10.1084/jem.20191688. J Exp Med. 2020. PMID: 32865561 Free PMC article.
SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
Hendriks IA, Treffers LW, Verlaan-de Vries M, Olsen JV, Vertegaal ACO. Hendriks IA, et al. Cell Rep. 2015 Mar 17;10(10):1778-1791. doi: 10.1016/j.celrep.2015.02.033. Epub 2015 Mar 12. Cell Rep. 2015. PMID: 25772364 Free PMC article.
20 results