Generation of complex bone marrow organoids from human induced pluripotent stem cells.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C.
Frenz-Wiessner S, et al.
Nat Methods. 2024 May;21(5):868-881. doi: 10.1038/s41592-024-02172-2. Epub 2024 Feb 19.
Nat Methods. 2024.
PMID: 38374263
Free PMC article.
The human bone marrow (BM) niche sustains hematopoiesis throughout life. ...We show that the BMOs could enable the modeling of hematopoietic developmental aspects and inborn errors of hematopoiesis, as shown for human VPS45 deficiency. Thus, iPSC-derived BMOs serve …
The human bone marrow (BM) niche sustains hematopoiesis throughout life. ...We show that the BMOs could enable the modeling of hemato …