6950/CRUK_/Cancer Research UK/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2008	1
2009	2
2010	2
2011	3
2012	6
2013	6
2014	3
2015	2
2016	1
2024	0

1

Mechanism-specific signatures for small-molecule p53 activators.

van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S. van Leeuwen IM, et al. Cell Cycle. 2011 May 15;10(10):1590-8. doi: 10.4161/cc.10.10.15519. Epub 2011 May 15. Cell Cycle. 2011. PMID: 21490429

2

Bivalent enzyme inhibitors discovered using dynamic covalent chemistry.

Clipson AJ, Bhat VT, McNae I, Caniard AM, Campopiano DJ, Greaney MF. Clipson AJ, et al. Chemistry. 2012 Aug 20;18(34):10562-70. doi: 10.1002/chem.201201507. Epub 2012 Jul 10. Chemistry. 2012. PMID: 22782854 Free article.

3

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.

McCarthy AR, Pirrie L, Hollick JJ, Ronseaux S, Campbell J, Higgins M, Staples OD, Tran F, Slawin AM, Lain S, Westwood NJ. McCarthy AR, et al. Bioorg Med Chem. 2012 Mar 1;20(5):1779-93. doi: 10.1016/j.bmc.2012.01.001. Epub 2012 Jan 12. Bioorg Med Chem. 2012. PMID: 22304848

4

ALDH2 mediates 5-nitrofuran activity in multiple species.

Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. Zhou L, et al. Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017. Chem Biol. 2012. PMID: 22840776 Free PMC article.

5

Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment.

Nortcliffe A, Ekstrom AG, Black JR, Ross JA, Habib FK, Botting NP, O'Hagan D. Nortcliffe A, et al. Bioorg Med Chem. 2014 Jan 15;22(2):756-61. doi: 10.1016/j.bmc.2013.12.014. Epub 2013 Dec 12. Bioorg Med Chem. 2014. PMID: 24387865

6

The benzyne aza-Claisen reaction.

Cant AA, Bertrand GH, Henderson JL, Roberts L, Greaney MF. Cant AA, et al. Angew Chem Int Ed Engl. 2009;48(28):5199-202. doi: 10.1002/anie.200901410. Angew Chem Int Ed Engl. 2009. PMID: 19526475

7

Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.

McCarthy AR, Sachweh MC, Higgins M, Campbell J, Drummond CJ, van Leeuwen IM, Pirrie L, Ladds MJ, Westwood NJ, Laín S. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60. doi: 10.1158/1535-7163.MCT-12-0900. Epub 2013 Jan 15. Mol Cancer Ther. 2013. PMID: 23322738

8

Flexible, phase-transfer catalyzed approaches to 4-substituted prolines.

Johnston HJ, McWhinnie FS, Landi F, Hulme AN. Johnston HJ, et al. Org Lett. 2014 Sep 19;16(18):4778-81. doi: 10.1021/ol502239g. Epub 2014 Sep 5. Org Lett. 2014. PMID: 25191962

9

Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues.

Monaghan D, O'Connell E, Cruickshank FL, O'Sullivan B, Giles FJ, Hulme AN, Fearnhead HO. Monaghan D, et al. Biochem Biophys Res Commun. 2014 Jan 10;443(2):761-7. doi: 10.1016/j.bbrc.2013.12.041. Epub 2013 Dec 12. Biochem Biophys Res Commun. 2014. PMID: 24333448 Free article.

10

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

Medda F, Russell RJ, Higgins M, McCarthy AR, Campbell J, Slawin AM, Lane DP, Lain S, Westwood NJ. Medda F, et al. J Med Chem. 2009 May 14;52(9):2673-82. doi: 10.1021/jm8014298. J Med Chem. 2009. PMID: 19419202 Free PMC article.

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