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2021 2
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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Haston S, Gonzalez-Gualda E, Morsli S, Ge J, Reen V, Calderwood A, Moutsopoulos I, Panousopoulos L, Deletic P, Carreno G, Guiho R, Manshaei S, Gonzalez-Meljem JM, Lim HY, Simpson DJ, Birch J, Pallikonda HA, Chandra T, Macias D, Doherty GJ, Rassl DM, Rintoul RC, Signore M, Mohorianu I, Akbar AN, Gil J, Muñoz-Espín D, Martinez-Barbera JP. Haston S, et al. Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6. doi: 10.1016/j.ccell.2023.05.004. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267953 Free article.
Targeting senescence as an anticancer therapy.
Bousset L, Gil J. Bousset L, et al. Mol Oncol. 2022 Nov;16(21):3855-3880. doi: 10.1002/1878-0261.13312. Epub 2022 Sep 23. Mol Oncol. 2022. PMID: 36065138 Free PMC article. Review.
3-Deazaadenosine keeps senescence at bay.
Guerrero A, Gil J. Guerrero A, et al. Aging (Albany NY). 2023 Mar 24;15(7):2369-2370. doi: 10.18632/aging.204625. Epub 2023 Mar 24. Aging (Albany NY). 2023. PMID: 36988502 Free PMC article. No abstract available.
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J. Guerrero A, et al. Nat Aging. 2022 Sep;2:851-866. doi: 10.1038/s43587-022-00279-9. Epub 2022 Sep 13. Nat Aging. 2022. PMID: 36438588 Free PMC article.
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence.
Innes AJ, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, Porreca RM, Dharmalingam G, Vernia S, Zuber J, Vannier JB, García-Escudero R, Gil J. Innes AJ, et al. Genes Dev. 2021 Mar 1;35(5-6):379-391. doi: 10.1101/gad.343269.120. Epub 2021 Feb 18. Genes Dev. 2021. PMID: 33602872 Free PMC article.