Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1823 1
1887 1
1930 1
1943 1
1944 3
1945 166
1946 356
1947 510
1948 675
1949 847
1950 1399
1951 1439
1952 1465
1953 1350
1954 1248
1955 1327
1956 1316
1957 1326
1958 1227
1959 677
1960 318
1961 299
1962 291
1963 772
1964 1289
1965 1277
1966 1121
1967 1216
1968 1317
1969 1303
1970 1303
1971 1320
1972 1250
1973 1076
1974 1057
1975 1078
1976 1098
1977 1148
1978 1179
1979 1202
1980 1139
1981 1150
1982 1242
1983 1252
1984 1326
1985 1337
1986 1394
1987 1340
1988 1394
1989 1409
1990 1406
1991 1260
1992 1235
1993 1212
1994 1188
1995 1138
1996 1170
1997 1200
1998 1168
1999 1201
2000 1222
2001 1288
2002 1304
2003 1400
2004 1492
2005 1628
2006 1904
2007 1873
2008 1912
2009 1894
2010 2162
2011 2389
2012 2428
2013 2846
2014 3949
2015 5101
2016 6610
2017 8048
2018 10125
2019 11706
2020 13058
2021 14483
2022 14718
2023 13715
2024 6614
2025 1

Text availability

Article attribute

Article type

Publication date

Search Results

181,388 results

Results by year

Filters applied: . Clear all
Page 1
CRISPR-Cas bioinformatics.
Alkhnbashi OS, Meier T, Mitrofanov A, Backofen R, Voß B. Alkhnbashi OS, et al. Methods. 2020 Feb 1;172:3-11. doi: 10.1016/j.ymeth.2019.07.013. Epub 2019 Jul 19. Methods. 2020. PMID: 31326596 Review.
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements. In rec …
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements …
A Review on the Mechanism and Applications of CRISPR/Cas9/Cas12/Cas13/Cas14 Proteins Utilized for Genome Engineering.
Hillary VE, Ceasar SA. Hillary VE, et al. Mol Biotechnol. 2023 Mar;65(3):311-325. doi: 10.1007/s12033-022-00567-0. Epub 2022 Sep 27. Mol Biotechnol. 2023. PMID: 36163606 Free PMC article. Review.
Cas variants stimulated genetic research and propelled the CRISPR/Cas tool for manipulating and editing nucleic acid sequences of living cells of diverse organisms. This review aims to provide detail on two classes (class 1 and 2) of the CRISPR/Cas system, an …
Cas variants stimulated genetic research and propelled the CRISPR/Cas tool for manipulating and editing nucleic acid sequences …
Design and analysis of CRISPR-Cas experiments.
Hanna RE, Doench JG. Hanna RE, et al. Nat Biotechnol. 2020 Jul;38(7):813-823. doi: 10.1038/s41587-020-0490-7. Epub 2020 Apr 13. Nat Biotechnol. 2020. PMID: 32284587 Review.
A large and ever-expanding set of CRISPR-Cas systems now enables the rapid and flexible manipulation of genomes in both targeted and large-scale experiments. Numerous software tools and analytical methods have been developed for the design and analysis of CRISPR-Cas …
A large and ever-expanding set of CRISPR-Cas systems now enables the rapid and flexible manipulation of genomes in both targeted and …
CRISPR-Cas for genome editing: Classification, mechanism, designing and applications.
Bhatia S, Pooja, Yadav SK. Bhatia S, et al. Int J Biol Macromol. 2023 May 31;238:124054. doi: 10.1016/j.ijbiomac.2023.124054. Epub 2023 Mar 17. Int J Biol Macromol. 2023. PMID: 36933595 Review.
The locus containing spacers interspersed repeats is further expressed into small guide CRISPR RNA (crRNA) which is then deployed by the Cas proteins to evade the target genome. Based on the Cas proteins CRISPR-Cas is classified according to polythetic system …
The locus containing spacers interspersed repeats is further expressed into small guide CRISPR RNA (crRNA) which is then deployed by the …
Annotation and Classification of CRISPR-Cas Systems.
Makarova KS, Koonin EV. Makarova KS, et al. Methods Mol Biol. 2015;1311:47-75. doi: 10.1007/978-1-4939-2687-9_4. Methods Mol Biol. 2015. PMID: 25981466 Free PMC article. Review.
To this end, a multipronged approach has been developed that combines phylogenetic analysis of the conserved Cas proteins with comparison of gene repertoires and arrangements in CRISPR-Cas loci. ...Moreover, most of the cas genes evolve rapidly, complicating …
To this end, a multipronged approach has been developed that combines phylogenetic analysis of the conserved Cas proteins with compar …
CRISPR-Cas System: The Current and Emerging Translational Landscape.
Bhokisham N, Laudermilch E, Traeger LL, Bonilla TD, Ruiz-Estevez M, Becker JR. Bhokisham N, et al. Cells. 2023 Apr 7;12(8):1103. doi: 10.3390/cells12081103. Cells. 2023. PMID: 37190012 Free PMC article. Review.
CRISPR-Cas technology has rapidly changed life science research and human medicine. ...Here, we review the current landscape of clinical trials involving the use of various CRISPR-Cas systems as therapeutics for human diseases, discuss challenges, and explore new CR …
CRISPR-Cas technology has rapidly changed life science research and human medicine. ...Here, we review the current landscape of clini …
Phage-Encoded Anti-CRISPR Defenses.
Stanley SY, Maxwell KL. Stanley SY, et al. Annu Rev Genet. 2018 Nov 23;52:445-464. doi: 10.1146/annurev-genet-120417-031321. Epub 2018 Sep 12. Annu Rev Genet. 2018. PMID: 30208287 Review.
In response to CRISPR-Cas, phages have evolved protein inhibitors known as anti-CRISPRs. ...We discuss the potential impact of anti-CRISPRs on bacterial evolution, speculate on their evolutionary origins, and contemplate the possible next steps in the CRISPR-Cas evo …
In response to CRISPR-Cas, phages have evolved protein inhibitors known as anti-CRISPRs. ...We discuss the potential impact of anti-C …
Functional Genomics via CRISPR-Cas.
Ford K, McDonald D, Mali P. Ford K, et al. J Mol Biol. 2019 Jan 4;431(1):48-65. doi: 10.1016/j.jmb.2018.06.034. Epub 2018 Jun 28. J Mol Biol. 2019. PMID: 29959923 Free PMC article. Review.
The programmability of CRISPR-Cas has proven especially useful for probing genomic function in high-throughput. ...As CRISPR-Cas technologies develop, so too will their clinical applications. ...
The programmability of CRISPR-Cas has proven especially useful for probing genomic function in high-throughput. ...As CRISPR-Cas …
The CRISPR-Cas system in Enterobacteriaceae.
Medina-Aparicio L, Dávila S, Rebollar-Flores JE, Calva E, Hernández-Lucas I. Medina-Aparicio L, et al. Pathog Dis. 2018 Feb 1;76(1). doi: 10.1093/femspd/fty002. Pathog Dis. 2018. PMID: 29325038 Review.
Much knowledge about the CRISPR-Cas system has been generated, including its biological functions, transcriptional regulation, distribution, utility as a molecular marker and as a tool for specific genome editing. This review focuses on these aspects and describes the stat …
Much knowledge about the CRISPR-Cas system has been generated, including its biological functions, transcriptional regulation, distri …
Applications of CRISPR-Cas Technologies to Proteomics.
Dolgalev G, Poverennaya E. Dolgalev G, et al. Genes (Basel). 2021 Nov 12;12(11):1790. doi: 10.3390/genes12111790. Genes (Basel). 2021. PMID: 34828396 Free PMC article. Review.
CRISPR-Cas-based genome editing is a revolutionary approach that has provided an unprecedented investigational power for the life sciences. ...In the second part of this review, we highlight both established and potential applications of the CRISPR-Cas technologies …
CRISPR-Cas-based genome editing is a revolutionary approach that has provided an unprecedented investigational power for the life sci …
181,388 results
You have reached the last available page of results. Please see the User Guide for more information.