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2020 3
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SARS-CoV-2 variants, spike mutations and immune escape.
Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, Ludden C, Reeve R, Rambaut A; COVID-19 Genomics UK (COG-UK) Consortium; Peacock SJ, Robertson DL. Harvey WT, et al. Nat Rev Microbiol. 2021 Jul;19(7):409-424. doi: 10.1038/s41579-021-00573-0. Epub 2021 Jun 1. Nat Rev Microbiol. 2021. PMID: 34075212 Free PMC article. Review.
Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study.
Nyberg T, Ferguson NM, Nash SG, Webster HH, Flaxman S, Andrews N, Hinsley W, Bernal JL, Kall M, Bhatt S, Blomquist P, Zaidi A, Volz E, Aziz NA, Harman K, Funk S, Abbott S; COVID-19 Genomics UK (COG-UK) consortium; Hope R, Charlett A, Chand M, Ghani AC, Seaman SR, Dabrera G, De Angelis D, Presanis AM, Thelwall S. Nyberg T, et al. Lancet. 2022 Apr 2;399(10332):1303-1312. doi: 10.1016/S0140-6736(22)00462-7. Epub 2022 Mar 16. Lancet. 2022. PMID: 35305296 Free PMC article.
CLIMB-COVID: continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance.
Nicholls SM, Poplawski R, Bull MJ, Underwood A, Chapman M, Abu-Dahab K, Taylor B, Colquhoun RM, Rowe WPM, Jackson B, Hill V, O'Toole Á, Rey S, Southgate J, Amato R, Livett R, Gonçalves S, Harrison EM, Peacock SJ, Aanensen DM, Rambaut A, Connor TR, Loman NJ; COVID-19 Genomics UK (COG-UK) Consortium. Nicholls SM, et al. Genome Biol. 2021 Jul 1;22(1):196. doi: 10.1186/s13059-021-02395-y. Genome Biol. 2021. PMID: 34210356 Free PMC article.
In response to the ongoing SARS-CoV-2 pandemic in the UK, the COVID-19 Genomics UK (COG-UK) consortium was formed to rapidly sequence SARS-CoV-2 genomes as part of a national-scale genomic surveillance strategy. ...We describe the development and deployment of CLIMB …
In response to the ongoing SARS-CoV-2 pandemic in the UK, the COVID-19 Genomics UK (COG-UK) consortium was formed to rapidly s …
Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer.
Wright DW, Harvey WT, Hughes J, Cox M, Peacock TP, Colquhoun R, Jackson B, Orton R, Nielsen M, Hsu NS; COVID-19 Genomics UK (COG-UK) consortium; Harrison EM, de Silva TI, Rambaut A, Peacock SJ, Robertson DL, Carabelli AM. Wright DW, et al. Virus Evol. 2022 Mar 18;8(1):veac023. doi: 10.1093/ve/veac023. eCollection 2022. Virus Evol. 2022. PMID: 35502202 Free PMC article.
COG-UK Mutation Explorer (COG-UK-ME, https://sars2.cvr.gla.ac.uk/cog-uk/-last accessed date 16 March 2022) is a web resource that displays knowledge and analyses on SARS-CoV-2 virus genome mutations and variants circulating in the UK, wit …
COG-UK Mutation Explorer (COG-UK-ME, https://sars2.cvr.gla.ac.uk/cog-uk/-last accessed date 16 Mar …
SARS-CoV-2 within-host diversity and transmission.
Lythgoe KA, Hall M, Ferretti L, de Cesare M, MacIntyre-Cockett G, Trebes A, Andersson M, Otecko N, Wise EL, Moore N, Lynch J, Kidd S, Cortes N, Mori M, Williams R, Vernet G, Justice A, Green A, Nicholls SM, Ansari MA, Abeler-Dörner L, Moore CE, Peto TEA, Eyre DW, Shaw R, Simmonds P, Buck D, Todd JA; Oxford Virus Sequencing Analysis Group (OVSG); Connor TR, Ashraf S, da Silva Filipe A, Shepherd J, Thomson EC; COVID-19 Genomics UK (COG-UK) Consortium; Bonsall D, Fraser C, Golubchik T. Lythgoe KA, et al. Science. 2021 Apr 16;372(6539):eabg0821. doi: 10.1126/science.abg0821. Epub 2021 Mar 9. Science. 2021. PMID: 33688063 Free PMC article.
Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study.
Stirrup O, Blackstone J, Mapp F, MacNeil A, Panca M, Holmes A, Machin N, Shin GY, Mahungu T, Saeed K, Saluja T, Taha Y, Mahida N, Pope C, Chawla A, Cutino-Moguel MT, Tamuri A, Williams R, Darby A, Robertson DL, Flaviani F, Nastouli E, Robson S, Smith D, Loose M, Laing K, Monahan I, Kele B, Haldenby S, George R, Bashton M, Witney AA, Byott M, Coll F, Chapman M, Peacock SJ; COG-UK HOCI Investigators; COVID-19 Genomics UK (COG-UK) consortium; Hughes J, Nebbia G, Partridge DG, Parker M, Price JR, Peters C, Roy S, Snell LB, de Silva TI, Thomson E, Flowers P, Copas A, Breuer J. Stirrup O, et al. Elife. 2022 Sep 13;11:e78427. doi: 10.7554/eLife.78427. Elife. 2022. PMID: 36098502 Free PMC article.
CONCLUSIONS: While we did not demonstrate a direct impact of sequencing on the incidence of nosocomial transmission, our results suggest that sequencing can inform IPC response to HOCIs, particularly when returned within 5 days. FUNDING: COG-UK is supported by fundi …
CONCLUSIONS: While we did not demonstrate a direct impact of sequencing on the incidence of nosocomial transmission, our results suggest tha …
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.
du Plessis L, McCrone JT, Zarebski AE, Hill V, Ruis C, Gutierrez B, Raghwani J, Ashworth J, Colquhoun R, Connor TR, Faria NR, Jackson B, Loman NJ, O'Toole Á, Nicholls SM, Parag KV, Scher E, Vasylyeva TI, Volz EM, Watts A, Bogoch II, Khan K; COVID-19 Genomics UK (COG-UK) Consortium; Aanensen DM, Kraemer MUG, Rambaut A, Pybus OG. du Plessis L, et al. Science. 2021 Feb 12;371(6530):708-712. doi: 10.1126/science.abf2946. Epub 2021 Jan 8. Science. 2021. PMID: 33419936 Free PMC article.
SARS-CoV-2 evolution during treatment of chronic infection.
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, Roberts DJ, Chandra A, Temperton N; CITIID-NIHR BioResource COVID-19 Collaboration; COVID-19 Genomics UK (COG-UK) Consortium; Sharrocks K, Blane E, Modis Y, Leigh KE, Briggs JAG, van Gils MJ, Smith KGC, Bradley JR, Smith C, Doffinger R, Ceron-Gutierrez L, Barcenas-Morales G, Pollock DD, Goldstein RA, Smielewska A, Skittrall JP, Gouliouris T, Goodfellow IG, Gkrania-Klotsas E, Illingworth CJR, McCoy LE, Gupta RK. Kemp SA, et al. Nature. 2021 Apr;592(7853):277-282. doi: 10.1038/s41586-021-03291-y. Epub 2021 Feb 5. Nature. 2021. PMID: 33545711 Free PMC article.
Recurrent SARS-CoV-2 mutations in immunodeficient patients.
Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L, Sparks N, Cumley N, Poplawski R, Nicholls SN, Kele B, Harris K, Peacock TP, Loman NJ. Wilkinson SAJ, et al. Virus Evol. 2022 Aug 11;8(2):veac050. doi: 10.1093/ve/veac050. eCollection 2022 Jul. Virus Evol. 2022. PMID: 35996593 Free PMC article.
This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identifying new case series directly from the COVID-19 Genomics UK (COG-UK) dataset. The spike gene receptor-binding domain and N-term …
This work aims to rectify this and study the genomics of this patient group through a combination of literature searches as well as identify …
Detecting SARS-CoV-2 variants with SNP genotyping.
Harper H, Burridge A, Winfield M, Finn A, Davidson A, Matthews D, Hutchings S, Vipond B, Jain N; COVID-19 Genomics UK (COG-UK) Consortium; Edwards K, Barker G. Harper H, et al. PLoS One. 2021 Feb 24;16(2):e0243185. doi: 10.1371/journal.pone.0243185. eCollection 2021. PLoS One. 2021. PMID: 33626040 Free PMC article.
73 results