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Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.
Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Damsky W, et al. Nat Commun. 2022 Jun 6;13(1):3140. doi: 10.1038/s41467-022-30615-x. Nat Commun. 2022. PMID: 35668129 Free PMC article. Clinical Trial.
Kynurenic acid may underlie sex-specific immune responses to COVID-19.
Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P; Yale IMPACT Research team; Ko AI, Khan SA, Iwasaki A, Johnson CH. Cai Y, et al. Sci Signal. 2021 Jul 6;14(690):eabf8483. doi: 10.1126/scisignal.abf8483. Sci Signal. 2021. PMID: 34230210 Free PMC article.
Kynurenic acid underlies sex-specific immune responses to COVID-19.
Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh J, Silva J, Wong P; Yale IMPACT Research team; Ko AI, Khan SA, Iwasaki A, Johnson CH. Cai Y, et al. medRxiv [Preprint]. 2020 Sep 8:2020.09.06.20189159. doi: 10.1101/2020.09.06.20189159. medRxiv. 2020. PMID: 32935119 Free PMC article. Updated. Preprint.