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Antagonism of the brain P2X7 ion channel attenuates repeated social defeat induced microglia reactivity, monocyte recruitment and anxiety-like behavior in male mice.
Brain Behav Immun. 2024 Jan;115:356-373. doi: 10.1016/j.bbi.2023.10.011. Epub 2023 Oct 31.
Brain Behav Immun. 2024.
PMID: 37914101
Unique brain endothelial profiles activated by social stress promote cell adhesion, prostaglandin E2 signaling, hypothalamic-pituitary-adrenal axis modulation, and anxiety.
Yin W, Swanson SP, Biltz RG, Goodman EJ, Gallagher NR, Sheridan JF, Godbout JP.
Yin W, et al.
Neuropsychopharmacology. 2022 Dec;47(13):2271-2282. doi: 10.1038/s41386-022-01434-x. Epub 2022 Sep 14.
Neuropsychopharmacology. 2022.
PMID: 36104533
Free PMC article.
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