GM077430/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2006	1
2007	1
2008	2
2009	2
2010	3
2011	2
2012	3
2013	4
2014	4
2015	2
2016	3
2017	2
2018	3
2019	1
2020	4
2021	2
2022	1
2023	2
2024	1

1

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.

Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Pratt WB, et al. Annu Rev Pharmacol Toxicol. 2015;55:353-71. doi: 10.1146/annurev-pharmtox-010814-124332. Epub 2014 Sep 25. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292434 Free PMC article. Review.

2

Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases.

Davis AK, Pratt WB, Lieberman AP, Osawa Y. Davis AK, et al. Cell Mol Life Sci. 2020 Mar;77(6):977-996. doi: 10.1007/s00018-019-03302-2. Epub 2019 Sep 24. Cell Mol Life Sci. 2020. PMID: 31552448 Free PMC article. Review.

3

A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.

Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2014 Nov;239(11):1405-13. doi: 10.1177/1535370214539444. Epub 2014 Jul 2. Exp Biol Med (Maywood). 2014. PMID: 24990484 Free PMC article. Review.

4

Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.

Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Davis AK, et al. Mol Pharmacol. 2020 Sep;98(3):243-249. doi: 10.1124/mol.120.119990. Epub 2020 Jun 26. Mol Pharmacol. 2020. PMID: 32591478 Free PMC article.

5

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.

Pratt WB, Morishima Y, Osawa Y. Pratt WB, et al. J Biol Chem. 2008 Aug 22;283(34):22885-9. doi: 10.1074/jbc.R800023200. Epub 2008 May 30. J Biol Chem. 2008. PMID: 18515355 Free PMC article. Review. No abstract available.

6

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.

Pratt WB, Morishima Y, Peng HM, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2010 Mar;235(3):278-89. doi: 10.1258/ebm.2009.009250. Exp Biol Med (Maywood). 2010. PMID: 20404045 Free PMC article. Review.

7

Functional characterization of the G162R and D216H genetic variants of human CYP17A1.

Capper CP, Liu J, McIntosh LR, Larios JM, Johnson MD, Hollenberg PF, Osawa Y, Auchus RJ, Rae JM. Capper CP, et al. J Steroid Biochem Mol Biol. 2018 Apr;178:159-166. doi: 10.1016/j.jsbmb.2017.12.002. Epub 2017 Dec 9. J Steroid Biochem Mol Biol. 2018. PMID: 29229304 Free PMC article.

8

Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.

Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Felker D, et al. Biophys Chem. 2021 Jul;274:106590. doi: 10.1016/j.bpc.2021.106590. Epub 2021 Apr 20. Biophys Chem. 2021. PMID: 33894563 Free PMC article.

9

Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.

Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Morishima Y, et al. Mol Pharmacol. 2018 Sep;94(3):984-991. doi: 10.1124/mol.118.112516. Epub 2018 Jun 25. Mol Pharmacol. 2018. PMID: 29941666 Free PMC article.

10

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.

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