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Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice.
Zelows MM, Cady C, Dharanipragada N, Mead AE, Kipp ZA, Bates EA, Varadharajan V, Banerjee R, Park SH, Shelman NR, Clarke HA, Hawkinson TR, Medina T, Sun RC, Lydic TA, Hinds TD Jr, Brown JM, Softic S, Graf GA, Helsley RN. Zelows MM, et al. Mol Metab. 2023 Dec;78:101815. doi: 10.1016/j.molmet.2023.101815. Epub 2023 Oct 4. Mol Metab. 2023. PMID: 37797918 Free PMC article.
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. Metabolism. 2023. PMID: 37230214
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. bioRxiv [Preprint]. 2023 Jan 27:2023.01.27.525605. doi: 10.1101/2023.01.27.525605. bioRxiv. 2023. PMID: 36747758 Free PMC article. Updated. Preprint.