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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
Proteomic analysis of Trypanosoma cruzi spliceosome complex.
Barbosa RL, da Cunha JPC, Menezes AT, Melo RFP, Elias MC, Silber AM, Coltri PP. Barbosa RL, et al. J Proteomics. 2020 Jul 15;223:103822. doi: 10.1016/j.jprot.2020.103822. Epub 2020 May 15. J Proteomics. 2020. PMID: 32422275
Protozoan persister-like cells and drug treatment failure.
Barrett MP, Kyle DE, Sibley LD, Radke JB, Tarleton RL. Barrett MP, et al. Nat Rev Microbiol. 2019 Oct;17(10):607-620. doi: 10.1038/s41579-019-0238-x. Epub 2019 Aug 23. Nat Rev Microbiol. 2019. PMID: 31444481 Free PMC article. Review.
Drug resistance in Leishmania: does it really matter?
Domagalska MA, Barrett MP, Dujardin JC. Domagalska MA, et al. Trends Parasitol. 2023 Apr;39(4):251-259. doi: 10.1016/j.pt.2023.01.012. Epub 2023 Feb 17. Trends Parasitol. 2023. PMID: 36803859 Review.
Drug Discovery for Kinetoplastid Diseases: Future Directions.
Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT. Rao SPS, et al. ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13. ACS Infect Dis. 2019. PMID: 30543391 Free article.
Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype.
Brooke DP, McGee LMC, Giordani F, Cross JM, Khalaf AI, Irving C, Gillingwater K, Shaw CD, Carter KC, Barrett MP, Suckling CJ, Scott FJ. Brooke DP, et al. RSC Med Chem. 2021 Jul 6;12(8):1391-1401. doi: 10.1039/d1md00110h. eCollection 2021 Aug 18. RSC Med Chem. 2021. PMID: 34447938 Free PMC article.
31 results