Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †.
Diukendjieva A, Zaharieva MM, Mori M, Alov P, Tsakovska I, Pencheva T, Najdenski H, Křen V, Felici C, Bufalieri F, Di Marcotullio L, Botta B, Botta M, Pajeva I.
Diukendjieva A, et al.
Antioxidants (Basel). 2020 May 5;9(5):384. doi: 10.3390/antiox9050384.
Antioxidants (Basel). 2020.
PMID: 32380762
Free PMC article.
This study combines in silico and in vitro methods to reveal the potential interactions of optically pure silybins and dehydrosilybins with novel protein targets. The shape and chemical similarity with approved drugs were evaluated in silico, and the potential for interact …
This study combines in silico and in vitro methods to reveal the potential interactions of optically pure silybins and dehydrosilybins with …