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2019 3
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Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.
Zengel J, Wang YX, Seo JW, Ning K, Hamilton JN, Wu B, Raie M, Holbrook C, Su S, Clements DR, Pillay S, Puschnik AS, Winslow MM, Idoyaga J, Nagamine CM, Sun Y, Mahajan VB, Ferrara KW, Blau HM, Carette JE. Zengel J, et al. Nat Methods. 2023 Jul;20(7):1070-1081. doi: 10.1038/s41592-023-01896-x. Epub 2023 Jun 8. Nat Methods. 2023. PMID: 37291262 Free PMC article.
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Wang R, et al. Cell. 2021 Jan 7;184(1):106-119.e14. doi: 10.1016/j.cell.2020.12.004. Epub 2020 Dec 9. Cell. 2021. PMID: 33333024 Free PMC article.
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Richards CM, et al. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. Science. 2022. PMID: 36074821 Free PMC article.
GPR108 Is a Highly Conserved AAV Entry Factor.
Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Dudek AM, et al. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. Mol Ther. 2020. PMID: 31784416 Free PMC article.
Enterovirus pathogenesis requires the host methyltransferase SETD3.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE. Diep J, et al. Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16. Nat Microbiol. 2019. PMID: 31527793 Free PMC article.
GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry.
Hartmann J, Thalheimer FB, Höpfner F, Kerzel T, Khodosevich K, García-González D, Monyer H, Diester I, Büning H, Carette JE, Fries P, Buchholz CJ. Hartmann J, et al. Mol Ther Methods Clin Dev. 2019 Jul 23;14:252-260. doi: 10.1016/j.omtm.2019.07.004. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31463334 Free PMC article.