R01 GM124149/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2017	1
2018	10
2019	8
2020	28
2021	17
2022	9
2023	12
2024	4

1

Large language models generate functional protein sequences across diverse families.

Madani A, Krause B, Greene ER, Subramanian S, Mohr BP, Holton JM, Olmos JL Jr, Xiong C, Sun ZZ, Socher R, Fraser JS, Naik N. Madani A, et al. Nat Biotechnol. 2023 Aug;41(8):1099-1106. doi: 10.1038/s41587-022-01618-2. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702895 Free PMC article.

2

A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.

Zhang Z, Rohweder PJ, Ongpipattanakul C, Basu K, Bohn MF, Dugan EJ, Steri V, Hann B, Shokat KM, Craik CS. Zhang Z, et al. Cancer Cell. 2022 Sep 12;40(9):1060-1069.e7. doi: 10.1016/j.ccell.2022.07.005. Cancer Cell. 2022. PMID: 36099883 Free PMC article.

3

Structural basis for dimerization quality control.

Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M. Mena EL, et al. Nature. 2020 Oct;586(7829):452-456. doi: 10.1038/s41586-020-2636-7. Epub 2020 Aug 19. Nature. 2020. PMID: 32814905 Free PMC article.

4

Discovery of allosteric binding sites by crystallographic fragment screening.

Krojer T, Fraser JS, von Delft F. Krojer T, et al. Curr Opin Struct Biol. 2020 Dec;65:209-216. doi: 10.1016/j.sbi.2020.08.004. Epub 2020 Nov 7. Curr Opin Struct Biol. 2020. PMID: 33171388 Free PMC article. Review.

5

Ligand binding remodels protein side-chain conformational heterogeneity.

Wankowicz SA, de Oliveira SH, Hogan DW, van den Bedem H, Fraser JS. Wankowicz SA, et al. Elife. 2022 Mar 21;11:e74114. doi: 10.7554/eLife.74114. Elife. 2022. PMID: 35312477 Free PMC article.

6

Bringing diffuse X-ray scattering into focus.

Wall ME, Wolff AM, Fraser JS. Wall ME, et al. Curr Opin Struct Biol. 2018 Jun;50:109-116. doi: 10.1016/j.sbi.2018.01.009. Epub 2018 Feb 16. Curr Opin Struct Biol. 2018. PMID: 29455056 Free PMC article. Review.

7

Spatially Patterned, Porous Protein Crystals as Multifunctional Materials.

Han K, Zhang Z, Tezcan FA. Han K, et al. J Am Chem Soc. 2023 Sep 13;145(36):19932-19944. doi: 10.1021/jacs.3c06348. Epub 2023 Aug 29. J Am Chem Soc. 2023. PMID: 37642457

8

Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures.

de la Mora E, Coquelle N, Bury CS, Rosenthal M, Holton JM, Carmichael I, Garman EF, Burghammer M, Colletier JP, Weik M. de la Mora E, et al. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4142-4151. doi: 10.1073/pnas.1821522117. Epub 2020 Feb 11. Proc Natl Acad Sci U S A. 2020. PMID: 32047034 Free PMC article.

9

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps.

Riley BT, Wankowicz SA, de Oliveira SHP, van Zundert GCP, Hogan DW, Fraser JS, Keedy DA, van den Bedem H. Riley BT, et al. Protein Sci. 2021 Jan;30(1):270-285. doi: 10.1002/pro.4001. Epub 2020 Nov 30. Protein Sci. 2021. PMID: 33210433 Free PMC article.

10

Evolution of a σ-(c-di-GMP)-anti-σ switch.

Schumacher MA, Gallagher KA, Holmes NA, Chandra G, Henderson M, Kysela DT, Brennan RG, Buttner MJ. Schumacher MA, et al. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2105447118. doi: 10.1073/pnas.2105447118. Proc Natl Acad Sci U S A. 2021. PMID: 34290147 Free PMC article.

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