R01 HL131690/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	4
2017	3
2018	2
2019	3
2020	2
2021	3
2022	1
2023	2
2024	0

1

Structural and functional insights into enzymes of the vitamin K cycle.

Tie JK, Stafford DW. Tie JK, et al. J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29. J Thromb Haemost. 2016. PMID: 26663892 Free PMC article. Review.

2

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase.

Jin DY, Chen X, Liu Y, Williams CM, Pedersen LC, Stafford DW, Tie JK. Jin DY, et al. Nat Commun. 2023 Feb 14;14(1):828. doi: 10.1038/s41467-023-36446-8. Nat Commun. 2023. PMID: 36788244 Free PMC article.

3

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement.

Xing H, Houston SD, Chen X, Ghassabian S, Fahrenhorst-Jones T, Kuo A, Murray CP, Conn KA, Jaeschke KN, Jin DY, Pasay C, Bernhardt PV, Burns JM, Tsanaktsidis J, Savage GP, Boyle GM, De Voss JJ, McCarthy J, Walter GH, Burne THJ, Smith MT, Tie JK, Williams CM. Xing H, et al. Chemistry. 2019 Feb 21;25(11):2729-2734. doi: 10.1002/chem.201806277. Epub 2019 Jan 25. Chemistry. 2019. PMID: 30681236 Free PMC article.

4

Determining the necessity of phenyl ring π-character in warfarin.

Xing H, Houston SD, Chen X, Jin DY, Savage GP, Tie JK, Williams CM. Xing H, et al. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1954-1956. doi: 10.1016/j.bmcl.2019.05.039. Epub 2019 May 23. Bioorg Med Chem Lett. 2019. PMID: 31147103 Free PMC article.

5

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions.

Cao Q, Hao Z, Li C, Chen X, Gao M, Jiang N, Liu H, Shen Y, Yang H, Zhang S, Yang A, Li W, Tie JK, Shen G. Cao Q, et al. J Thromb Haemost. 2023 Nov;21(11):3124-3137. doi: 10.1016/j.jtha.2023.06.021. Epub 2023 Jun 29. J Thromb Haemost. 2023. PMID: 37393002

6

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins.

Hao Z, Jin DY, Chen X, Schurgers LJ, Stafford DW, Tie JK. Hao Z, et al. Blood. 2021 Jan 28;137(4):533-543. doi: 10.1182/blood.2020006329. Blood. 2021. PMID: 33507293 Free PMC article.

7

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation.

Chen X, Furukawa N, Jin DY, Liu Y, Stafford DW, Williams CM, Suhara Y, Tie JK. Chen X, et al. FEBS J. 2022 May;289(9):2613-2627. doi: 10.1111/febs.16291. Epub 2021 Dec 1. FEBS J. 2022. PMID: 34813684 Free PMC article.

8

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition.

Wu S, Chen X, Jin DY, Stafford DW, Pedersen LG, Tie JK. Wu S, et al. Blood. 2018 Aug 9;132(6):647-657. doi: 10.1182/blood-2018-01-830901. Epub 2018 May 9. Blood. 2018. PMID: 29743176 Free PMC article.

9

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle.

Chen X, Li C, Jin DY, Ingram B, Hao Z, Bai X, Stafford DW, Hu K, Tie JK. Chen X, et al. Blood. 2020 Aug 13;136(7):898-908. doi: 10.1182/blood.2019004234. Blood. 2020. PMID: 32374827 Free PMC article.

10

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase.

Chen X, Liu Y, Furukawa N, Jin DY, Paul Savage G, Stafford DW, Suhara Y, Williams CM, Tie JK. Chen X, et al. J Thromb Haemost. 2021 Mar;19(3):689-700. doi: 10.1111/jth.15209. Epub 2021 Jan 22. J Thromb Haemost. 2021. PMID: 33314621 Free PMC article.

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