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The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.
Neurochem Int. 2008 Sep;53(3-4):79-88. doi: 10.1016/j.neuint.2008.06.003. Epub 2008 Jun 12.
Neurochem Int. 2008.
PMID: 18590784
Free PMC article.
Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity.
Nicholson AM, Ferreira A.
Nicholson AM, et al.
J Neurosci. 2009 Apr 8;29(14):4640-51. doi: 10.1523/JNEUROSCI.0862-09.2009.
J Neurosci. 2009.
PMID: 19357288
Free PMC article.
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