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Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.
Jaworski JP, Krebs SJ, Trovato M, Kovarik DN, Brower Z, Sutton WF, Waagmeester G, Sartorius R, D'Apice L, Caivano A, Doria-Rose NA, Malherbe D, Montefiori DC, Barnett S, De Berardinis P, Haigwood NL. Jaworski JP, et al. PLoS One. 2012;7(2):e31464. doi: 10.1371/journal.pone.0031464. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359593 Free PMC article.
HIV-1 Gag p17 presented as virus-like particles on the E2 scaffold from Geobacillus stearothermophilus induces sustained humoral and cellular immune responses in the absence of IFNγ production by CD4+ T cells.
Caivano A, Doria-Rose NA, Buelow B, Sartorius R, Trovato M, D'Apice L, Domingo GJ, Sutton WF, Haigwood NL, De Berardinis P. Caivano A, et al. Virology. 2010 Nov 25;407(2):296-305. doi: 10.1016/j.virol.2010.08.026. Epub 2010 Sep 20. Virology. 2010. PMID: 20850858 Free PMC article.