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RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent.
J Allergy Clin Immunol. 2023 Nov;152(5):1261-1272. doi: 10.1016/j.jaci.2023.06.024. Epub 2023 Jul 15.
J Allergy Clin Immunol. 2023.
PMID: 37460023
Free PMC article.
NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.
Sharfe N, Dalal I, Naghdi Z, Lefaudeux D, Vong L, Dadi H, Navarro H, Tasher D, Ovadia A, Zangen T, Ater D, Ngan B, Hoffmann A, Roifman CM.
Sharfe N, et al.
J Autoimmun. 2023 May;137:102946. doi: 10.1016/j.jaut.2022.102946. Epub 2022 Nov 17.
J Autoimmun. 2023.
PMID: 36402602
Free PMC article.
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