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Year Number of Results
2018 1
2019 6
2020 8
2021 19
2022 19
2023 18
2024 7

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Page 1
Senolytic drugs: from discovery to translation.
Kirkland JL, Tchkonia T. Kirkland JL, et al. J Intern Med. 2020 Nov;288(5):518-536. doi: 10.1111/joim.13141. Epub 2020 Aug 4. J Intern Med. 2020. PMID: 32686219 Free PMC article. Review.
Cellular senescence: the good, the bad and the unknown.
Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Huang W, et al. Nat Rev Nephrol. 2022 Oct;18(10):611-627. doi: 10.1038/s41581-022-00601-z. Epub 2022 Aug 3. Nat Rev Nephrol. 2022. PMID: 35922662 Free PMC article. Review.
Strategies for Targeting Senescent Cells in Human Disease.
Gasek NS, Kuchel GA, Kirkland JL, Xu M. Gasek NS, et al. Nat Aging. 2021 Oct;1(10):870-879. doi: 10.1038/s43587-021-00121-8. Epub 2021 Oct 7. Nat Aging. 2021. PMID: 34841261 Free PMC article. Review.
Cellular senescence: at the nexus between ageing and diabetes.
Palmer AK, Gustafson B, Kirkland JL, Smith U. Palmer AK, et al. Diabetologia. 2019 Oct;62(10):1835-1841. doi: 10.1007/s00125-019-4934-x. Epub 2019 Aug 27. Diabetologia. 2019. PMID: 31451866 Free PMC article. Review.
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Zhu Y, et al. EBioMedicine. 2022 Mar;77:103912. doi: 10.1016/j.ebiom.2022.103912. Epub 2022 Mar 13. EBioMedicine. 2022. PMID: 35292270 Free PMC article.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
67 results