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Transcription factors interact with RNA to regulate genes.
Oksuz O, Henninger JE, Warneford-Thomson R, Zheng MM, Erb H, Vancura A, Overholt KJ, Hawken SW, Banani SF, Lauman R, Reich LN, Robertson AL, Hannett NM, Lee TI, Zon LI, Bonasio R, Young RA. Oksuz O, et al. Mol Cell. 2023 Jul 20;83(14):2449-2463.e13. doi: 10.1016/j.molcel.2023.06.012. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402367
Bat pluripotent stem cells reveal unusual entanglement between host and viruses.
Déjosez M, Marin A, Hughes GM, Morales AE, Godoy-Parejo C, Gray JL, Qin Y, Singh AA, Xu H, Juste J, Ibáñez C, White KM, Rosales R, Francoeur NJ, Sebra RP, Alcock D, Volkert TL, Puechmaille SJ, Pastusiak A, Frost SDW, Hiller M, Young RA, Teeling EC, García-Sastre A, Zwaka TP. Déjosez M, et al. Cell. 2023 Mar 2;186(5):957-974.e28. doi: 10.1016/j.cell.2023.01.011. Epub 2023 Feb 21. Cell. 2023. PMID: 36812912 Free PMC article.
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
Dejosez M, Dall'Agnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, Brosh R, Weintraub AS, Hnisz D, Abraham BJ, Young RA, Zwaka TP. Dejosez M, et al. Cell Rep. 2023 May 30;42(5):112505. doi: 10.1016/j.celrep.2023.112505. Epub 2023 May 12. Cell Rep. 2023. PMID: 37182209 Free PMC article.
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. Dall'Agnese A, et al. Nat Commun. 2022 Dec 6;13(1):7522. doi: 10.1038/s41467-022-35176-7. Nat Commun. 2022. PMID: 36473871 Free PMC article.
Protein codes promote selective subcellular compartmentalization.
Kilgore HR, Chinn I, Mikhael PG, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee TI, Barzilay R, Young RA. Kilgore HR, et al. bioRxiv [Preprint]. 2024 May 22:2024.04.15.589616. doi: 10.1101/2024.04.15.589616. bioRxiv. 2024. PMID: 38659952 Free PMC article. Preprint.