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Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire.
Ou T, He W, Quinlan BD, Guo Y, Tran MH, Karunadharma P, Park H, Davis-Gardner ME, Yin Y, Zhang X, Wang H, Zhong G, Farzan M. Ou T, et al. Mol Ther. 2022 Jan 5;30(1):184-197. doi: 10.1016/j.ymthe.2021.10.027. Epub 2021 Nov 2. Mol Ther. 2022. PMID: 34740791 Free PMC article.
A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020.
Tran MH, Park H, Nobles CL, Karunadharma P, Pan L, Zhong G, Wang H, He W, Ou T, Crynen G, Sheptack K, Stiskin I, Mou H, Farzan M. Tran MH, et al. Mol Ther Nucleic Acids. 2021 Feb 18;24:40-53. doi: 10.1016/j.omtn.2021.02.012. eCollection 2021 Jun 4. Mol Ther Nucleic Acids. 2021. PMID: 33738137 Free PMC article.
eCD4-Ig Variants That More Potently Neutralize HIV-1.
Fetzer I, Gardner MR, Davis-Gardner ME, Prasad NR, Alfant B, Weber JA, Farzan M. Fetzer I, et al. J Virol. 2018 May 29;92(12):e02011-17. doi: 10.1128/JVI.02011-17. Print 2018 Jun 15. J Virol. 2018. PMID: 29593050 Free PMC article.
AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges.
Gardner MR, Fellinger CH, Kattenhorn LM, Davis-Gardner ME, Weber JA, Alfant B, Zhou AS, Prasad NR, Kondur HR, Newton WA, Weisgrau KL, Rakasz EG, Lifson JD, Gao G, Schultz-Darken N, Farzan M. Gardner MR, et al. Sci Transl Med. 2019 Jul 24;11(502):eaau5409. doi: 10.1126/scitranslmed.aau5409. Sci Transl Med. 2019. PMID: 31341061 Free PMC article.
26 results