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Lipid hydroperoxides promote sarcopenia through carbonyl stress.
Eshima H, Shahtout JL, Siripoksup P, Pearson MJ, Mahmassani ZS, Ferrara PJ, Lyons AW, Maschek JA, Peterlin AD, Verkerke ARP, Johnson JM, Salcedo A, Petrocelli JJ, Miranda ER, Anderson EJ, Boudina S, Ran Q, Cox JE, Drummond MJ, Funai K. Eshima H, et al. Elife. 2023 Mar 23;12:e85289. doi: 10.7554/eLife.85289. Elife. 2023. PMID: 36951533 Free PMC article.
Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice.
McKenzie AI, Reidy PT, Nelson DS, Mulvey JL, Yonemura NM, Petrocelli JJ, Mahmassani ZS, Tippetts TS, Summers SA, Funai K, Drummond MJ. McKenzie AI, et al. Am J Physiol Regul Integr Comp Physiol. 2020 Mar 1;318(3):R503-R511. doi: 10.1152/ajpregu.00330.2019. Epub 2020 Jan 29. Am J Physiol Regul Integr Comp Physiol. 2020. PMID: 31994900 Free PMC article.
Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism.
Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. Siripoksup P, et al. J Clin Invest. 2024 Apr 23;134(11):e167371. doi: 10.1172/JCI167371. J Clin Invest. 2024. PMID: 38652544 Free PMC article.
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.
Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. Ferrara PJ, et al. J Clin Invest. 2021 Apr 15;131(8):e135963. doi: 10.1172/JCI135963. J Clin Invest. 2021. PMID: 33591957 Free PMC article.