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Catalytic in vivo protein knockdown by small-molecule PROTACs.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Bondeson DP, et al. Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10. Nat Chem Biol. 2015. PMID: 26075522 Free PMC article.
Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology.
Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA. Jülich D, et al. Dev Cell. 2015 Jul 6;34(1):33-44. doi: 10.1016/j.devcel.2015.05.005. Epub 2015 Jun 18. Dev Cell. 2015. PMID: 26096733 Free PMC article.
Tau mutants bind tubulin heterodimers with enhanced affinity.
Elbaum-Garfinkle S, Cobb G, Compton JT, Li XH, Rhoades E. Elbaum-Garfinkle S, et al. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6311-6. doi: 10.1073/pnas.1315983111. Epub 2014 Apr 14. Proc Natl Acad Sci U S A. 2014. PMID: 24733915 Free PMC article.
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM. Lai AC, et al. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10. doi: 10.1002/anie.201507634. Epub 2015 Nov 23. Angew Chem Int Ed Engl. 2016. PMID: 26593377 Free PMC article.
12 results