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11,149 results

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Page 1
Showing results for a wuhan m
Search for A Puhan M instead (1 results)
Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function.
Yin R, Chang J, Li Y, Gao Z, Qiu Q, Wang Q, Han G, Chai J, Feng M, Wang P, Zhang T, Xie X, Hu J, Cheng Y, Guo C, Wang J, Gao K, Cui M, Li S, Zheng Y, Jiang W, Hu Y, Yang QY, Zhang H. Yin R, et al. Cell Stem Cell. 2022 Jan 6;29(1):149-159.e7. doi: 10.1016/j.stem.2021.09.014. Epub 2021 Oct 21. Cell Stem Cell. 2022. PMID: 34678169 Free article.
N(6)-methyladenosine (m(6)A) on mRNA plays critical roles in various cellular processes. ...Our data reveal a cell-type-specific m(6)A landscape in hematopoiesis. m(6)A modifications arise mostly in the early stage of hematopoiesis and prefer to play distinct …
N(6)-methyladenosine (m(6)A) on mRNA plays critical roles in various cellular processes. ...Our data reveal a cell-type-specific m …
Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.
Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H. Cheng Y, et al. Cell Stem Cell. 2023 Jan 5;30(1):69-85.e7. doi: 10.1016/j.stem.2022.12.003. Epub 2022 Dec 26. Cell Stem Cell. 2023. PMID: 36574771 Free article.
However, dynamics of m(6)A RNA methylome during leukemogenesis remains unknown. Here, we delineate a comprehensive m(6)A landscape during acute myeloid leukemia (AML) development and identify PRMT6 as a key for maintaining AML stem cells. We observe an obvious chang …
However, dynamics of m(6)A RNA methylome during leukemogenesis remains unknown. Here, we delineate a comprehensive m(6)A lands …
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.
Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y. Shan T, et al. Mol Cell. 2023 Dec 21;83(24):4494-4508.e6. doi: 10.1016/j.molcel.2023.10.040. Epub 2023 Nov 27. Mol Cell. 2023. PMID: 38016476
By quantifying the m(6)A level of polysomal and cytoplasmic mRNAs with m(6)A-LAIC-seq and m(6)A-LC-MS/MS in HeLa cells, we observed that polysome-associated mRNAs are hypo-m(6)A-methylated, whereas those enriched in P-body are hyper-m(6)A-methyl …
By quantifying the m(6)A level of polysomal and cytoplasmic mRNAs with m(6)A-LAIC-seq and m(6)A-LC-MS/MS in HeLa cells, …
Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway.
Qu Z, Zhou J, Zhou Y, Xie Y, Jiang Y, Wu J, Luo Z, Liu G, Yin L, Zhang XL. Qu Z, et al. Sci Adv. 2020 Oct 23;6(43):eaba4733. doi: 10.1126/sciadv.aba4733. Print 2020 Oct. Sci Adv. 2020. PMID: 33097533 Free PMC article.
However, macrophage pyroptosis-related proteins from Mycobacterium tuberculosis (M.tb) have largely gone unexplored. Here, we identified a cell pyroptosis-inducing protein, Rv1579c, named EST12, secreted from the M.tb H37Rv region of difference 3. ...An EST12-defici …
However, macrophage pyroptosis-related proteins from Mycobacterium tuberculosis (M.tb) have largely gone unexplored. Here, we identif …
ALKBH5-mediated m(6)A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis.
Zhang H, Liu Y, Wang W, Liu F, Wang W, Su C, Zhu H, Liao Z, Zhang B, Chen X. Zhang H, et al. Cell Death Dis. 2022 Nov 5;13(11):926. doi: 10.1038/s41419-022-05386-4. Cell Death Dis. 2022. PMID: 36335087 Free PMC article.
As the most important RNA epigenetic regulation in eukaryotic cells, N6-metheyladenosine (m(6)A) modification has been demonstrated to play significant roles in cancer progression. ...Thus, ALKBH5-mediated LINC02551 m(6)A methylation was required for HCC growth and …
As the most important RNA epigenetic regulation in eukaryotic cells, N6-metheyladenosine (m(6)A) modification has been demonstrated t …
RNA Modification by m(6)A Methylation in Cardiovascular Disease.
Chen J, Wei X, Yi X, Jiang DS. Chen J, et al. Oxid Med Cell Longev. 2021 Feb 9;2021:8813909. doi: 10.1155/2021/8813909. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34221238 Free PMC article. Review.
After the initial identification of m(6)A RNA methylation in 1974, the rise of next-generation sequencing technology to detect m(6)A throughout the transcriptome led to its renewed recognition in 2012. ...Finally, we discuss future directions for m(6)A methyl …
After the initial identification of m(6)A RNA methylation in 1974, the rise of next-generation sequencing technology to detect m …
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, Wang Q, Hu J, Cheng Y, Zhang T, Li Y, Gao Z, Guo C, Wang J, Liang J, Cui M, Gao K, Chai J, Liu W, Cheng H, Li L, Zhou F, Liu L, Luo Y, Li S, Zhang H. Wang J, et al. Cell Stem Cell. 2020 Jul 2;27(1):81-97.e8. doi: 10.1016/j.stem.2020.04.001. Epub 2020 May 12. Cell Stem Cell. 2020. PMID: 32402251 Free article.
N(6)-methyladenosine (m(6)A) is a commonly present modification of mammalian mRNAs and plays key roles in various cellular processes. m(6)A modifiers catalyze this reversible modification. ...Moreover, ALKBH5 affects mRNA stability of receptor tyrosine kinase AXL in …
N(6)-methyladenosine (m(6)A) is a commonly present modification of mammalian mRNAs and plays key roles in various cellular processes. …
Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing.
Li S, Wang X, Yan Z, Wang T, Chen Z, Song H, Zheng Y. Li S, et al. Adv Sci (Weinh). 2023 Aug;10(22):e2300576. doi: 10.1002/advs.202300576. Epub 2023 May 18. Adv Sci (Weinh). 2023. PMID: 37202594 Free PMC article.
Results show that PFG/M MNs eradicate bacterial infections and modulate the immune microenvironment, combining the advantages of chemodynamic therapy, photothermal therapy, and M2 macrophage polarization from Fe/PDA@GOx@HA in the tips as well as anti-inflammatory effect of …
Results show that PFG/M MNs eradicate bacterial infections and modulate the immune microenvironment, combining the advantages of chem …
RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia.
Yin R, Li Y, Tian W, Zhou F, Zhang H. Yin R, et al. Blood Sci. 2022 Jul 20;4(3):116-124. doi: 10.1097/BS9.0000000000000131. eCollection 2022 Jul. Blood Sci. 2022. PMID: 36518594 Free PMC article.
The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m(6)A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m(6)A biology by focusing on writer …
The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m(6)A modification in a …
Intertwined regulation between RNA m(6)A modification and cancer metabolism.
Liu J, Huang H, Zhang M, Qing G, Liu H. Liu J, et al. Cell Insight. 2022 Dec 5;2(1):100075. doi: 10.1016/j.cellin.2022.100075. eCollection 2023 Feb. Cell Insight. 2022. PMID: 37192910 Free PMC article. Review.
RNA N6-methyladenosine (m(6)A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). ...In this review, we summarize the most recent advances of how RNA methylation affe …
RNA N6-methyladenosine (m(6)A) has been identified as the most common, abundant and conserved internal modification in RNA transcript …
11,149 results
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