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Showing results for abeta kk
Search for Abeya KK instead (1 results)
Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.
Innes KE, Selfe TK, Brundage K, Montgomery C, Wen S, Kandati S, Bowles H, Khalsa DS, Huysmans Z. Innes KE, et al. J Alzheimers Dis. 2018;66(3):947-970. doi: 10.3233/JAD-180164. J Alzheimers Dis. 2018. PMID: 30320574 Free PMC article. Clinical Trial.
RESULTS: Baseline blood samples were available for 53 participants (25 KK, 28 ML). The KK group showed significantly greater increases in Abeta40 than the ML group. ...Both groups improved in cognitive and psychosocial status (ps 0.05), with improvements in stress, …
RESULTS: Baseline blood samples were available for 53 participants (25 KK, 28 ML). The KK group showed significantly greater i …
Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.
Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galán-Echevarría F, Karz A, Argibay D, Von Itter R, Floristán A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos RB, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E. Kleffman K, et al. Cancer Discov. 2022 May 2;12(5):1314-1335. doi: 10.1158/2159-8290.CD-21-1006. Cancer Discov. 2022. PMID: 35262173 Free PMC article.
Our unbiased proteomics analysis of melanoma short-term cultures revealed that proteins implicated in neurodegenerative pathologies are differentially expressed in melanoma cells explanted from brain metastases compared with those derived from extracranial metastases. We showed t …
Our unbiased proteomics analysis of melanoma short-term cultures revealed that proteins implicated in neurodegenerative pathologies are diff …
β-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies.
Diaz-Galvan P, Przybelski SA, Lesnick TG, Schwarz CG, Senjem ML, Gunter JL, Jack CR, Min HP, Jain M, Miyagawa T, Forsberg LK, Fields JA, Savica R, Graff-Radford J, Jones DT, Botha H, St Louis EK, Knopman DS, Ramanan VK, Ross O, Graff-Radford N, Day GS, Dickson DW, Ferman TJ, Petersen RC, Lowe VJ, Boeve BF, Kantarci K. Diaz-Galvan P, et al. Neurology. 2023 Jul 11;101(2):e178-e188. doi: 10.1212/WNL.0000000000207393. Epub 2023 May 18. Neurology. 2023. PMID: 37202168
BACKGROUND AND OBJECTIVES: beta-Amyloid (Abeta) plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy bodies (DLB), but Abeta load at prodromal stages of DLB still needs to be elucidated. ...Specifically, APOE epsilon4 carriers had hig …
BACKGROUND AND OBJECTIVES: beta-Amyloid (Abeta) plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy …
Cerebral Microbleed Patterns and Cortical Amyloid-β: The ARIC-PET Study.
Okine DN, Knopman DS, Mosley TH, Wong DF, Johansen MC, Walker KA, Jack CR Jr, Kantarci K, Pike JR, Graff-Radford J, Gottesman RF. Okine DN, et al. Stroke. 2023 Oct;54(10):2613-2620. doi: 10.1161/STROKEAHA.123.042835. Epub 2023 Aug 28. Stroke. 2023. PMID: 37638398 Free article.
We evaluated the cross-sectional association between CMB patterns and cerebral Abeta (amyloid-beta) deposition, by florbetapir positron emission tomography. ...Magnetic resonance imaging images were read for CMBs and superficial siderosis; on positron emission tomography, …
We evaluated the cross-sectional association between CMB patterns and cerebral Abeta (amyloid-beta) deposition, by florbetapir positr …
Recombinant Integrin beta1 Signal Peptide Blocks Gliosis Induced by Abeta Oligomers.
Ortiz-Sanz C, Llavero F, Zuazo-Ibarra J, Balantzategi U, Quintela-López T, Wyssenbach A, Capetillo-Zarate E, Matute C, Alberdi E, Zugaza JL. Ortiz-Sanz C, et al. Int J Mol Sci. 2022 May 20;23(10):5747. doi: 10.3390/ijms23105747. Int J Mol Sci. 2022. PMID: 35628557 Free PMC article.
A recent study from our laboratory reports that astrocyte reactivity is caused by a direct interaction between amyloid beta (Abeta) oligomers and integrin beta1. Here, we have generated four recombinant peptides including the extracellular domain of integrin beta1, and eva …
A recent study from our laboratory reports that astrocyte reactivity is caused by a direct interaction between amyloid beta (Abeta) o …
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.
Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T. Hata S, et al. EMBO Mol Med. 2023 May 8;15(5):e17052. doi: 10.15252/emmm.202217052. Epub 2023 Mar 30. EMBO Mol Med. 2023. PMID: 36994913 Free PMC article.
Brain peptide p3-Alcbeta37 is generated from the neuronal protein alcadein beta through cleavage of gamma-secretase, similar to the generation of amyloid beta (Abeta) derived from Abeta-protein precursor/APP. Neurotoxicity by Abeta oligomers (Abetao) is the p …
Brain peptide p3-Alcbeta37 is generated from the neuronal protein alcadein beta through cleavage of gamma-secretase, similar to the generati …
Mass Spectrometry Imaging in Alzheimer's Disease.
Ikegawa M, Kakuda N, Miyasaka T, Toyama Y, Nirasawa T, Minta K, Hanrieder J. Ikegawa M, et al. Brain Connect. 2023 Aug;13(6):319-333. doi: 10.1089/brain.2022.0057. Epub 2023 Apr 24. Brain Connect. 2023. PMID: 36905365
Introduction: Amyloid-beta (Abeta) pathology is the precipitating histopathological characteristic of Alzheimer's disease (AD). ...Despite the close relationship between vascular and plaque Abeta deposition, the current strategy will define cross talk between neurod …
Introduction: Amyloid-beta (Abeta) pathology is the precipitating histopathological characteristic of Alzheimer's disease (AD). ...De …
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.
Gonzalez-Ortiz F, Kirsebom BE, Contador J, Tanley JE, Selnes P, Gísladóttir B, Pålhaugen L, Suhr Hemminghyth M, Jarholm J, Skogseth R, Bråthen G, Grøndtvedt G, Bjørnerud A, Tecelao S, Waterloo K, Aarsland D, Fernández-Lebrero A, García-Escobar G, Navalpotro-Gómez I, Turton M, Hesthamar A, Kac PR, Nilsson J, Luchsinger J, Hayden KM, Harrison P, Puig-Pijoan A, Zetterberg H, Hughes TM, Suárez-Calvet M, Karikari TK, Fladby T, Blennow K. Gonzalez-Ortiz F, et al. Nat Commun. 2024 Apr 4;15(1):2908. doi: 10.1038/s41467-024-47286-5. Nat Commun. 2024. PMID: 38575616 Free PMC article.
In blood, phosphorylated tau (p-tau) associates with Abeta pathophysiology but an AD-type neurodegeneration biomarker has been lacking. ...Here we show that blood-based BD-tau is a biomarker for identifying Abeta-positive individuals at risk of short-term cognitive …
In blood, phosphorylated tau (p-tau) associates with Abeta pathophysiology but an AD-type neurodegeneration biomarker has been lackin …
Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer's Disease.
Tanaka M, Saito S, Inoue T, Satoh-Asahara N, Ihara M. Tanaka M, et al. Int J Mol Sci. 2020 Mar 14;21(6):1992. doi: 10.3390/ijms21061992. Int J Mol Sci. 2020. PMID: 32183348 Free PMC article. Review.
Despite extensive studies to explore drugs targeting Abeta, clinical benefits have not been reported in large clinical trials in AD patients or presymptomatic individuals at a risk for AD. ...This work has revealed potential therapeutic targets, including Abeta drai …
Despite extensive studies to explore drugs targeting Abeta, clinical benefits have not been reported in large clinical trials in AD p …
Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid.
Yaari R, Holdridge KC, Choi J, Donohue MC, Kantarci K, Jack CR Jr, Zuk SM, Sims JR, Johnson KA, Aisen PS, Sperling RA. Yaari R, et al. J Prev Alzheimers Dis. 2022;9(4):617-624. doi: 10.14283/jpad.2022.56. J Prev Alzheimers Dis. 2022. PMID: 36281665 Free PMC article. Clinical Trial.
In the Abeta+ cohort, approximately 2% of screening MRIs demonstrated MCH 4 compared with 0% in Abeta-. ...ARIA-H in Abeta+ was greater than in Abeta- populations....
In the Abeta+ cohort, approximately 2% of screening MRIs demonstrated MCH 4 compared with 0% in Abeta-. ...ARIA-H in Abeta …
69 results