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Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial.
Behr J, Prasse A, Kreuter M, Johow J, Rabe KF, Bonella F, Bonnet R, Grohe C, Held M, Wilkens H, Hammerl P, Koschel D, Blaas S, Wirtz H, Ficker JH, Neumeister W, Schönfeld N, Claussen M, Kneidinger N, Frankenberger M, Hummler S, Kahn N, Tello S, Freise J, Welte T, Neuser P, Günther A; RELIEF investigators. Behr J, et al. Lancet Respir Med. 2021 May;9(5):476-486. doi: 10.1016/S2213-2600(20)30554-3. Epub 2021 Mar 30. Lancet Respir Med. 2021. PMID: 33798455 Clinical Trial.
Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis.
Bahudhanapati H, Tan J, Apel RM, Seeliger B, Schupp J, Li X, Sullivan DI, Sembrat J, Rojas M, Tabib T, Valenzi E, Lafyatis R, Mitash N, Hernandez Pineda R, Jawale C, Peroumal D, Biswas P, Tedrow J, Adams T, Kaminski N, Wuyts WA, McDyer JF, Gibson KF, Alder JK, Königshoff M, Zhang Y, Nouraie M, Prasse A, Kass DJ. Bahudhanapati H, et al. Among authors: apel rm. Eur Respir J. 2024 Jan 4;63(1):2300088. doi: 10.1183/13993003.00088-2023. Print 2024 Jan. Eur Respir J. 2024. PMID: 37918852
Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis.
Scharm SC, Vogel-Claussen J, Schaefer-Prokop C, Dettmer S, Knudsen L, Jonigk D, Fuge J, Apel RM, Welte T, Wacker F, Prasse A, Shin HO. Scharm SC, et al. Among authors: apel rm. Eur Radiol. 2021 Sep;31(9):6640-6651. doi: 10.1007/s00330-021-07798-w. Epub 2021 Mar 16. Eur Radiol. 2021. PMID: 33725189 Free PMC article.