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CTLA-4 can function as a negative regulator of T cell activation.
Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. Walunas TL, et al. Among authors: bakker cy. Immunity. 1994 Aug;1(5):405-13. doi: 10.1016/1074-7613(94)90071-x. Immunity. 1994. PMID: 7882171
CTLA-4 ligation blocks CD28-dependent T cell activation.
Walunas TL, Bakker CY, Bluestone JA. Walunas TL, et al. Among authors: bakker cy. J Exp Med. 1996 Jun 1;183(6):2541-50. doi: 10.1084/jem.183.6.2541. J Exp Med. 1996. PMID: 8676075 Free PMC article.