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The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.
Peacock TP, Goldhill DH, Zhou J, Baillon L, Frise R, Swann OC, Kugathasan R, Penn R, Brown JC, Sanchez-David RY, Braga L, Williamson MK, Hassard JA, Staller E, Hanley B, Osborn M, Giacca M, Davidson AD, Matthews DA, Barclay WS. Peacock TP, et al. Among authors: barclay ws. Nat Microbiol. 2021 Jul;6(7):899-909. doi: 10.1038/s41564-021-00908-w. Epub 2021 Apr 27. Nat Microbiol. 2021. PMID: 33907312
IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators; Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Everitt AR, et al. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Nature. 2012. PMID: 22446628 Free PMC article.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, Hué S, Barclay WS, Schulz R, Malim MH. Goujon C, et al. Among authors: barclay ws. Nature. 2013 Oct 24;502(7472):559-62. doi: 10.1038/nature12542. Epub 2013 Sep 18. Nature. 2013. PMID: 24048477 Free PMC article.
Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance.
Frise R, Bradley K, van Doremalen N, Galiano M, Elderfield RA, Stilwell P, Ashcroft JW, Fernandez-Alonso M, Miah S, Lackenby A, Roberts KL, Donnelly CA, Barclay WS. Frise R, et al. Among authors: barclay ws. Sci Rep. 2016 Jul 19;6:29793. doi: 10.1038/srep29793. Sci Rep. 2016. PMID: 27430528 Free PMC article.
Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics.
Peacock TP, Benton DJ, James J, Sadeyen JR, Chang P, Sealy JE, Bryant JE, Martin SR, Shelton H, Barclay WS, Iqbal M. Peacock TP, et al. Among authors: barclay ws. J Virol. 2017 Jun 26;91(14):e00218-17. doi: 10.1128/JVI.00218-17. Print 2017 Jul 15. J Virol. 2017. PMID: 28468875 Free PMC article.
278 results