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Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.
Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C. Nimmrich V, et al. Among authors: barghorn s. J Neurosci. 2008 Jan 23;28(4):788-97. doi: 10.1523/JNEUROSCI.4771-07.2008. J Neurosci. 2008. PMID: 18216187 Free PMC article.
Abnormal accumulation of soluble oligomers of amyloid beta (Abeta) is believed to cause malfunctioning of neurons in Alzheimer's disease. It has been shown that Abeta oligomers impair synaptic plasticity, thereby altering the ability of the neuron to store information. ... …
Abnormal accumulation of soluble oligomers of amyloid beta (Abeta) is believed to cause malfunctioning of neurons in Alzheimer's dise …
Structural characterization of a soluble amyloid beta-peptide oligomer.
Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET. Yu L, et al. Among authors: barghorn s. Biochemistry. 2009 Mar 10;48(9):1870-7. doi: 10.1021/bi802046n. Biochemistry. 2009. PMID: 19216516
Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.
Hillen H, Barghorn S, Striebinger A, Labkovsky B, Müller R, Nimmrich V, Nolte MW, Perez-Cruz C, van der Auwera I, van Leuven F, van Gaalen M, Bespalov AY, Schoemaker H, Sullivan JP, Ebert U. Hillen H, et al. Among authors: barghorn s. J Neurosci. 2010 Aug 4;30(31):10369-79. doi: 10.1523/JNEUROSCI.5721-09.2010. J Neurosci. 2010. PMID: 20685980 Free PMC article.
Abeta-globulomers are formed independently of the fibril pathway.
Gellermann GP, Byrnes H, Striebinger A, Ullrich K, Mueller R, Hillen H, Barghorn S. Gellermann GP, et al. Among authors: barghorn s. Neurobiol Dis. 2008 May;30(2):212-20. doi: 10.1016/j.nbd.2008.01.010. Epub 2008 Feb 15. Neurobiol Dis. 2008. PMID: 18353662
Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA.
Almagro JC, Gilliland GL, Breden F, Scott JK, Sok D, Pauthner M, Reichert JM, Helguera G, Andrabi R, Mabry R, Bléry M, Voss JE, Laurén J, Abuqayyas L, Barghorn S, Ben-Jacob E, Crowe JE Jr, Huston JS, Johnston SA, Krauland E, Lund-Johansen F, Marasco WA, Parren PW, Xu KY. Almagro JC, et al. Among authors: barghorn s. MAbs. 2014 May-Jun;6(3):577-618. doi: 10.4161/mabs.28421. Epub 2014 Mar 3. MAbs. 2014. PMID: 24589717 Free PMC article.
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