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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1958 1
1959 3
1961 2
1962 4
1963 14
1964 30
1965 29
1966 35
1967 48
1968 38
1969 46
1970 55
1971 95
1972 114
1973 131
1974 229
1975 1135
1976 1118
1977 1184
1978 1171
1979 1161
1980 1734
1981 2270
1982 2632
1983 2814
1984 3113
1985 3483
1986 3787
1987 4093
1988 4704
1989 5441
1990 6002
1991 6660
1992 7585
1993 8429
1994 9751
1995 10800
1996 11734
1997 12473
1998 13782
1999 14643
2000 16114
2001 17193
2002 18055
2003 19877
2004 21850
2005 22550
2006 21924
2007 23293
2008 24695
2009 26541
2010 28538
2011 30673
2012 33312
2013 35209
2014 35341
2015 35429
2016 20322
2017 14276
2018 23816
2019 24424
2020 24026
2021 22878
2022 18781
2023 15154
2024 2971

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654,487 results

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Page 1
Showing results for kinase u
Search for Binase U instead (2 results)
FDA-approved small-molecule kinase inhibitors.
Wu P, Nielsen TE, Clausen MH. Wu P, et al. Trends Pharmacol Sci. 2015 Jul;36(7):422-39. doi: 10.1016/j.tips.2015.04.005. Epub 2015 May 12. Trends Pharmacol Sci. 2015. PMID: 25975227 Review.
Kinases have emerged as one of the most intensively pursued targets in current pharmacological research, especially for cancer, due to their critical roles in cellular signaling. To date, the US FDA has approved 28 small-molecule kinase inhibitors, half of which wer …
Kinases have emerged as one of the most intensively pursued targets in current pharmacological research, especially for cancer, due t …
High-sensitivity measurements of multiple kinase activities in live single cells.
Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. Regot S, et al. Cell. 2014 Jun 19;157(7):1724-34. doi: 10.1016/j.cell.2014.04.039. Cell. 2014. PMID: 24949979 Free PMC article.
Our reporters reproduce kinase activity for multiple types of kinases and allow for calculation of active kinase concentrations via a mathematical model. ...Our approach opens the possibility of analyzing a wide range of kinase-mediated processes in in …
Our reporters reproduce kinase activity for multiple types of kinases and allow for calculation of active kinase concen …
Two-component signal transduction.
Stock AM, Robinson VL, Goudreau PN. Stock AM, et al. Annu Rev Biochem. 2000;69:183-215. doi: 10.1146/annurev.biochem.69.1.183. Annu Rev Biochem. 2000. PMID: 10966457 Review.
Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein. The histidine protein kinase, which is regulated by environmental …
Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a …
Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer.
Lin W, Mehta S, Zhang J. Lin W, et al. J Biol Chem. 2019 Oct 4;294(40):14814-14822. doi: 10.1074/jbc.REV119.006177. Epub 2019 Aug 21. J Biol Chem. 2019. PMID: 31434714 Free PMC article. Review.
Accordingly, genetically encoded fluorescent biosensors capable of directly illuminating the spatiotemporal dynamics of kinase signaling in live cells are being increasingly used to investigate kinase signaling in cancer cells and tumor tissue sections. ...These ver …
Accordingly, genetically encoded fluorescent biosensors capable of directly illuminating the spatiotemporal dynamics of kinase signal …
KinaseMD: kinase mutations and drug response database.
Hu R, Xu H, Jia P, Zhao Z. Hu R, et al. Nucleic Acids Res. 2021 Jan 8;49(D1):D552-D561. doi: 10.1093/nar/gkaa945. Nucleic Acids Res. 2021. PMID: 33137204 Free PMC article.
Somatic mutations in kinase genes can affect drug treatment, both sensitivity and resistance, to clinically used kinase inhibitors. ...KinaseMD integrates 679 374 somatic mutations, 251 522 network-rewiring events, and 390 460 drug response records curated from vari …
Somatic mutations in kinase genes can affect drug treatment, both sensitivity and resistance, to clinically used kinase inhibi …
Kinase mutations in human disease: interpreting genotype-phenotype relationships.
Lahiry P, Torkamani A, Schork NJ, Hegele RA. Lahiry P, et al. Nat Rev Genet. 2010 Jan;11(1):60-74. doi: 10.1038/nrg2707. Nat Rev Genet. 2010. PMID: 20019687 Review.
Here we survey kinase gene mutations from the perspective of human disease phenotypes and further analyse the structural features of mutant kinases, including mutational hotspots. Our evaluation of the genotype-phenotype relationship across 915 human kinase m …
Here we survey kinase gene mutations from the perspective of human disease phenotypes and further analyse the structural features of …
Non-ATP competitive protein kinase inhibitors.
Garuti L, Roberti M, Bottegoni G. Garuti L, et al. Curr Med Chem. 2010;17(25):2804-21. doi: 10.2174/092986710791859333. Curr Med Chem. 2010. PMID: 20586715 Review.
Protein kinases represent an attractive target in oncology drug discovery. Most of kinase inhibitors are ATP-competitive and are called type I inhibitors. ...
Protein kinases represent an attractive target in oncology drug discovery. Most of kinase inhibitors are ATP-competitive and a …
KEA: kinase enrichment analysis.
Lachmann A, Ma'ayan A. Lachmann A, et al. Bioinformatics. 2009 Mar 1;25(5):684-6. doi: 10.1093/bioinformatics/btp026. Epub 2009 Jan 28. Bioinformatics. 2009. PMID: 19176546 Free PMC article.
By computing how the proportion of kinases, associated with a specific list of proteins/genes, deviates from an expected distribution, we can rank kinases and kinase families based on the likelihood that these kinases are functionally associated with r …
By computing how the proportion of kinases, associated with a specific list of proteins/genes, deviates from an expected distribution …
Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors.
Tripathi DK, Poluri KM. Tripathi DK, et al. Front Biosci (Landmark Ed). 2020 Mar 1;25(7):1361-1385. doi: 10.2741/4860. Front Biosci (Landmark Ed). 2020. PMID: 32114437 Free article. Review.
The regulation of chemokine receptor is also governed by kinases like protein kinase A (PKA), protein kinase C (PKC), mitogen-activated protein kinases / extracellular signal-regulated kinases (MAPK/ERK), etc. ...On a similar note, many others l …
The regulation of chemokine receptor is also governed by kinases like protein kinase A (PKA), protein kinase C (PKC), m …
Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling.
Nagpal L, Kornberg MD, Snyder SH. Nagpal L, et al. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2121946119. doi: 10.1073/pnas.2121946119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353626 Free PMC article.
Inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks), of which IP6K2 has been implicated in various cellular functions including neuroprotection. ...Knockdown of IP6K2 also lead …
Inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of inositol hexakisphosphate kina …
654,487 results
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