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Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
van Hall T, Wolpert EZ, van Veelen P, Laban S, van der Veer M, Roseboom M, Bres S, Grufman P, de Ru A, Meiring H, de Jong A, Franken K, Teixeira A, Valentijn R, Drijfhout JW, Koning F, Camps M, Ossendorp F, Kärre K, Ljunggren HG, Melief CJ, Offringa R. van Hall T, et al. Among authors: bres s. Nat Med. 2006 Apr;12(4):417-24. doi: 10.1038/nm1381. Epub 2006 Mar 19. Nat Med. 2006. PMID: 16550190
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells.
Medema JP, Schuurhuis DH, Rea D, van Tongeren J, de Jong J, Bres SA, Laban S, Toes RE, Toebes M, Schumacher TN, Bladergroen BA, Ossendorp F, Kummer JA, Melief CJ, Offringa R. Medema JP, et al. Among authors: bres sa. J Exp Med. 2001 Sep 3;194(5):657-67. doi: 10.1084/jem.194.5.657. J Exp Med. 2001. PMID: 11535633 Free PMC article.
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors.
Medema JP, de Jong J, Peltenburg LT, Verdegaal EM, Gorter A, Bres SA, Franken KL, Hahne M, Albar JP, Melief CJ, Offringa R. Medema JP, et al. Among authors: bres sa. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11515-20. doi: 10.1073/pnas.201398198. Epub 2001 Sep 18. Proc Natl Acad Sci U S A. 2001. PMID: 11562487 Free PMC article.