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Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.
Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH. Tostanoski LH, et al. Among authors: chan cn. Nat Med. 2020 Nov;26(11):1694-1700. doi: 10.1038/s41591-020-1070-6. Epub 2020 Sep 3. Nat Med. 2020. PMID: 32884153 Free PMC article.
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.
Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini M. Harper J, et al. Among authors: chan cn. Nat Med. 2020 Apr;26(4):519-528. doi: 10.1038/s41591-020-0782-y. Epub 2020 Mar 16. Nat Med. 2020. PMID: 32284611 Free PMC article.
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Collagen in the Mesenteric Lymph Nodes of Nonhuman Primates.
Scholz EMB, Mwangi JN, De la Cruz G, Nekorchuk M, Chan CN, Busman-Sahay K, Adamson L, Luciw P, Fedoriw Y, Estes JD, Rosen EP, Kashuba ADM. Scholz EMB, et al. Among authors: chan cn. Antimicrob Agents Chemother. 2021 May 18;65(6):e00019-21. doi: 10.1128/AAC.00019-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33782003 Free PMC article.
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.
Aid M, Vidal SJ, Piedra-Mora C, Ducat S, Chan CN, Bondoc S, Colarusso A, Starke CE, Nekorchuk M, Busman-Sahay K, Estes JD, Martinot AJ, Barouch DH. Aid M, et al. Among authors: chan cn. PLoS Pathog. 2022 Apr 8;18(4):e1009990. doi: 10.1371/journal.ppat.1009990. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35395058 Free PMC article.
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments.
Jiang S, Chan CN, Rovira-Clavé X, Chen H, Bai Y, Zhu B, McCaffrey E, Greenwald NF, Liu C, Barlow GL, Weirather JL, Oliveria JP, Nakayama T, Lee IT, Matter MS, Carlisle AE, Philips D, Vazquez G, Mukherjee N, Busman-Sahay K, Nekorchuk M, Terry M, Younger S, Bosse M, Demeter J, Rodig SJ, Tzankov A, Goltsev Y, McIlwain DR, Angelo M, Estes JD, Nolan GP. Jiang S, et al. Among authors: chan cn. Immunity. 2022 Jun 14;55(6):1118-1134.e8. doi: 10.1016/j.immuni.2022.03.020. Epub 2022 Apr 20. Immunity. 2022. PMID: 35447093 Free PMC article.
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes.
Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, Nyengaard JR, Estes JD, Abdel-Mohsen M, Østergaard L, Tolstrup M, Søgaard OS, Denton PW. Schleimann MH, et al. Among authors: chan cn. EBioMedicine. 2019 Jul;45:328-340. doi: 10.1016/j.ebiom.2019.07.005. Epub 2019 Jul 9. EBioMedicine. 2019. PMID: 31300344 Free PMC article. Clinical Trial.
Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.
Harper J, Ribeiro SP, Chan CN, Aid M, Deleage C, Micci L, Pino M, Cervasi B, Raghunathan G, Rimmer E, Ayanoglu G, Wu G, Shenvi N, Barnard RJ, Del Prete GQ, Busman-Sahay K, Silvestri G, Kulpa DA, Bosinger SE, Easley KA, Howell BJ, Gorman D, Hazuda DJ, Estes JD, Sekaly RP, Paiardini M. Harper J, et al. Among authors: chan cn. J Clin Invest. 2022 Apr 15;132(8):e155251. doi: 10.1172/JCI155251. J Clin Invest. 2022. PMID: 35230978 Free PMC article.
53 results