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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E. Frezza C, et al. Among authors: chaneton b. Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363. Nature. 2011. PMID: 21849978
Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E. Chaneton B, et al. Nature. 2012 Nov 15;491(7424):458-462. doi: 10.1038/nature11540. Epub 2012 Oct 14. Nature. 2012. PMID: 23064226 Free PMC article.
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.
Baenke F, Chaneton B, Smith M, Van Den Broek N, Hogan K, Tang H, Viros A, Martin M, Galbraith L, Girotti MR, Dhomen N, Gottlieb E, Marais R. Baenke F, et al. Among authors: chaneton b. Mol Oncol. 2016 Jan;10(1):73-84. doi: 10.1016/j.molonc.2015.08.003. Epub 2015 Aug 20. Mol Oncol. 2016. PMID: 26365896 Free PMC article.
Modeling cancer metabolism on a genome scale.
Yizhak K, Chaneton B, Gottlieb E, Ruppin E. Yizhak K, et al. Among authors: chaneton b. Mol Syst Biol. 2015 Jun 30;11(6):817. doi: 10.15252/msb.20145307. Mol Syst Biol. 2015. PMID: 26130389 Free PMC article. Review.
Tumoral prostate shows different expression pattern of somatostatin receptor 2 (SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor progression.
Cariaga-Martinez AE, Lorenzati MA, Riera MA, Cubilla MA, De La Rossa A, Giorgio EM, Tiscornia MM, Gimenez EM, Rojas ME, Chaneton BJ, Rodríguez DI, Zapata PD. Cariaga-Martinez AE, et al. Among authors: chaneton bj. Adv Urol. 2009;2009:723831. doi: 10.1155/2009/723831. Epub 2009 Apr 12. Adv Urol. 2009. PMID: 19365586 Free PMC article.