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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Koenig PA, et al. Among authors: christensen mh. Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. Science. 2021. PMID: 33436526 Free PMC article.
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.
Bosso M, Prelli Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, Sauter D, Kirchhoff F. Bosso M, et al. Among authors: christensen mh. PLoS Pathog. 2020 Aug 6;16(8):e1008752. doi: 10.1371/journal.ppat.1008752. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32760121 Free PMC article.
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Hayn M, et al. Among authors: christensen mh. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33974846 Free PMC article.
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: christensen mh. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production.
Reinert LS, Rashidi AS, Tran DN, Katzilieris-Petras G, Hvidt AK, Gohr M, Fruhwürth S, Bodda C, Thomsen MK, Vendelbo MH, Khan AR, Hansen B, Bergström P, Agholme L, Mogensen TH, Christensen MH, Nyengaard JR, Sen GC, Zetterberg H, Verjans GM, Paludan SR. Reinert LS, et al. Among authors: christensen mh. J Clin Invest. 2021 Jan 4;131(1):e136824. doi: 10.1172/JCI136824. J Clin Invest. 2021. PMID: 32990676 Free PMC article.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR. Prabakaran T, et al. Among authors: christensen mh. EMBO J. 2018 Apr 13;37(8):e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1. EMBO J. 2018. PMID: 29496741 Free PMC article.
cGAS is activated by DNA in a length-dependent manner.
Luecke S, Holleufer A, Christensen MH, Jønsson KL, Boni GA, Sørensen LK, Johannsen M, Jakobsen MR, Hartmann R, Paludan SR. Luecke S, et al. Among authors: christensen mh. EMBO Rep. 2017 Oct;18(10):1707-1715. doi: 10.15252/embr.201744017. Epub 2017 Aug 10. EMBO Rep. 2017. PMID: 28801534 Free PMC article.
75 results