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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1891 1
1945 1
1946 7
1947 13
1948 19
1949 21
1950 104
1951 77
1952 149
1953 126
1954 172
1955 156
1956 186
1957 185
1958 185
1959 97
1960 56
1961 66
1962 103
1963 538
1964 755
1965 783
1966 740
1967 861
1968 979
1969 1053
1970 1041
1971 1098
1972 1249
1973 1052
1974 977
1975 1105
1976 1007
1977 949
1978 848
1979 838
1980 938
1981 766
1982 884
1983 813
1984 957
1985 900
1986 880
1987 839
1988 803
1989 906
1990 906
1991 893
1992 913
1993 896
1994 923
1995 969
1996 940
1997 1008
1998 992
1999 1065
2000 1017
2001 1119
2002 1140
2003 1158
2004 1225
2005 1337
2006 1233
2007 1321
2008 1415
2009 1433
2010 1469
2011 1559
2012 1683
2013 1872
2014 1849
2015 1836
2016 1873
2017 1878
2018 1944
2019 2072
2020 2213
2021 2342
2022 2369
2023 2260
2024 900

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71,973 results

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Page 1
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
NAD(+) homeostasis in human health and disease.
Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. Zapata-Pérez R, et al. EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 34041853 Free PMC article. Review.
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to other factors affecting NAD(+) homeostasis, such as increased NAD(+) consumption or dietary deficiency of its vitamin B3 precurso …
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to oth …
The kynurenine pathway: a finger in every pie.
Savitz J. Savitz J. Mol Psychiatry. 2020 Jan;25(1):131-147. doi: 10.1038/s41380-019-0414-4. Epub 2019 Apr 12. Mol Psychiatry. 2020. PMID: 30980044 Free PMC article. Review.
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system. ...
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD …
NAD(+) Metabolism in Cardiac Health, Aging, and Disease.
Abdellatif M, Sedej S, Kroemer G. Abdellatif M, et al. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. Circulation. 2021. PMID: 34843394
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgenic overexpression of NAD(+)-generating enzymes have wide positive effects on metabolic health and age-associated diseases. ...Here, w …
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgen …
NAD metabolism: Role in senescence regulation and aging.
Chini CCS, Cordeiro HS, Tran NLK, Chini EN. Chini CCS, et al. Aging Cell. 2024 Jan;23(1):e13920. doi: 10.1111/acel.13920. Epub 2023 Jul 9. Aging Cell. 2024. PMID: 37424179 Free PMC article. Review.
The relationship between NAD metabolism and cellular senescence appears to be complex. On the one hand, the accumulation of DNA damage and mitochondrial dysfunction induced by low NAD(+) can promote the development of senescence. ...Therefore, to explore the implica …
The relationship between NAD metabolism and cellular senescence appears to be complex. On the one hand, the accumulation of DNA damag …
NAD(+) regulates nucleotide metabolism and genomic DNA replication.
Munk SHN, Merchut-Maya JM, Adelantado Rubio A, Hall A, Pappas G, Milletti G, Lee M, Johnsen LG, Guldberg P, Bartek J, Maya-Mendoza A. Munk SHN, et al. Nat Cell Biol. 2023 Dec;25(12):1774-1786. doi: 10.1038/s41556-023-01280-z. Epub 2023 Nov 13. Nat Cell Biol. 2023. PMID: 37957325 Free PMC article.
As a co-enzyme, NAD(+) plays a key role in regulating metabolic pathways, such as glycolysis and Kreb's cycle. ...The activation of PARP1 in response to DNA breaks leads to rapid depletion of cellular NAD(+) compromising cell viability. Therefore, the levels of N …
As a co-enzyme, NAD(+) plays a key role in regulating metabolic pathways, such as glycolysis and Kreb's cycle. ...The activation of P …
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S. Pencina KM, et al. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. J Clin Endocrinol Metab. 2023. PMID: 36740954 Clinical Trial.
CONTEXT: Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related decline in NAD has been postulated to contribute to age-related diseases. ...These data provide the rationale for larger trials to assess the efficacy of NAD augmentati …
CONTEXT: Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related decline in NAD has been postulated …
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.
Bhasin S, Seals D, Migaud M, Musi N, Baur JA. Bhasin S, et al. Endocr Rev. 2023 Nov 9;44(6):1047-1073. doi: 10.1210/endrev/bnad019. Endocr Rev. 2023. PMID: 37364580 Review.
NAD+ levels decrease throughout life; age-related decline in NAD+ bioavailability has been postulated to be a contributor to many age-related diseases. ...Clinical pharmacology, metabolism, and therapeutic mechanisms of NAD+ precursors remain incompletely und …
NAD+ levels decrease throughout life; age-related decline in NAD+ bioavailability has been postulated to be a contributor to m …
NAD(+) Precursors in Human Health and Disease: Current Status and Future Prospects.
Yaku K, Nakagawa T. Yaku K, et al. Antioxid Redox Signal. 2023 Dec;39(16-18):1133-1149. doi: 10.1089/ars.2023.0354. Epub 2023 Aug 4. Antioxid Redox Signal. 2023. PMID: 37335049 Review.
In addition, in vivo studies of NAD(+) metabolism have rapidly progressed. Critical Issues: Several studies have demonstrated that the oral administration of NAD(+) precursors, such as NR and NMN, is safe and significantly increases NAD(+) levels in humans. . …
In addition, in vivo studies of NAD(+) metabolism have rapidly progressed. Critical Issues: Several studies have demonstrated that th …
NAD(+)-Consuming Enzymes in Stem Cell Homeostasis.
Ji X, Zheng M, Yu T, Kang J, Fan T, Xu B. Ji X, et al. Oxid Med Cell Longev. 2023 Feb 8;2023:4985726. doi: 10.1155/2023/4985726. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 36819783 Free PMC article. Review.
NAD(+) is also required as a cofactor by nonredox NAD(+)-dependent enzymes. ...In this review, we discussed how different types of NAD(+)-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD(+) consumers in SC …
NAD(+) is also required as a cofactor by nonredox NAD(+)-dependent enzymes. ...In this review, we discussed how different type …
71,973 results
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